SV40 T Ag Antibody (LP7N): sc-53447
- SV40 T Ag Antibody (LP7N) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against detergent insoluble fraction of SVK14 cell line
- recommended for detection of large T antigen of SV40 origin by WB, IP and IF
- See SV40 T Ag (Pab 101): sc-147 for SV40 T Ag antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for SV40 T Ag Antibody (LP7N) for WB applications. This reagent is now offered in a bundle with SV40 T Ag Antibody (LP7N) (see ordering information below).
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SV40 T Ag Antibody (LP7N) is a mouse monoclonal IgG1 antibody that detects SV40 T Ag of SV40 species reactivity by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). SV40 T Ag plays a crucial role in the viral life cycle and is essential for the transformation of host cells, as SV40 T Ag interacts with key cellular proteins that regulate cell growth and division. Notably, SV40 T Ag binds to the retinoblastoma (Rb) protein, specifically targeting the "pocket" domain, which is also the binding site for the E2F transcription factor. This interaction leads to the inactivation of Rb, disrupting Rb′s ability to regulate the cell cycle and promoting uncontrolled cell proliferation. Additionally, SV40 T Ag′s ability to form complexes with other tumor suppressor proteins, such as p53, further underscores SV40 T Ag′s importance in oncogenic processes. Anti-SV40 T Ag antibody (LP7N) serves as an invaluable tool for researchers studying the mechanisms of viral oncogenesis and the intricate pathways involved in cellular transformation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SV40 T Ag Antibody (LP7N) | sc-53447 | 200 µg/ml | $322.00 | |||
SV40 T Ag Antibody (LP7N): m-IgG Fc BP-HRP Bundle | sc-538991 | 200 µg Ab; 10 µg BP | $361.00 |