SV2B Antibody (F-7): sc-166104

SV2B Antibody (F-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects SV2B in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SV2B Antibody (F-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SV2B, a member of the synaptic vesicle protein family, plays a crucial role in synaptic transmission by regulating calcium ion levels in presynaptic nerve terminals, which is essential for neurotransmitter release. SV2B is predominantly localized to synaptic vesicles in the brain, particularly in a subset of synapses within the hippocampus and cortex, where SV2B contributes to the fine-tuning of synaptic activity. The functional redundancy between SV2A and SV2B underscores their importance in maintaining normal brain function, as both proteins are necessary for effective synaptic communication. The specific expression pattern of SV2B, in contrast to the more widespread SV2A, highlights SV2B′s specialized role in certain neuronal circuits, making SV2B a valuable target for studying synaptic mechanisms and potential neurological disorders.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SV2B Antibody (F-7) References:

1. Synaptic vesicle protein SV2B, but not SV2A, is predominantly expressed and associated with microvesicles in rat pinealocytes.  |  Hayashi, M., et al. 1999. Adv Exp Med Biol. 460: 91-3. PMID: 10810505
2. Identification of a novel fusion gene involving RUNX1 and the antisense strand of SV2B in a BCR-ABL1-positive acute leukemia.  |  Giguère, A. and Hébert, J. 2013. Genes Chromosomes Cancer. 52: 1114-22. PMID: 24123676
3. Role of DHA in aging-related changes in mouse brain synaptic plasma membrane proteome.  |  Sidhu, VK., et al. 2016. Neurobiol Aging. 41: 73-85. PMID: 27103520
4. Environmental Enrichment Upregulates Striatal Synaptic Vesicle-Associated Proteins and Improves Motor Function.  |  Song, SY., et al. 2018. Front Neurol. 9: 465. PMID: 30061854
5. Evaluating the In Vivo Specificity of [18F]UCB-H for the SV2A Protein, Compared with SV2B and SV2C in Rats Using microPET.  |  Serrano, ME., et al. 2019. Molecules. 24: PMID: 31052478
6. Synaptic Vesicle Protein 2B Negatively Regulates the Amyloidogenic Processing of AβPP as a Novel Interaction Partner of BACE1.  |  Miyamoto, M., et al. 2020. J Alzheimers Dis. 75: 173-185. PMID: 32280101
7. Altered Brain Cholinergic and Synaptic Markers in Obese Zucker Rats.  |  Martinelli, I., et al. 2021. Cells. 10: PMID: 34685507
8. SV2B/miR-34a/miR-128 axis as prognostic biomarker in glioblastoma multiforme.  |  Mustafov, D., et al. 2024. Sci Rep. 14: 6647. PMID: 38503772
9. Coexistence of a novel SV2B-ALK, EML4-ALK double-fusion in a lung poorly differentiated adenocarcinoma patient and response to alectinib: a case report and literature review.  |  Chen, H., et al. 2024. Front Oncol. 14: 1453259. PMID: 39735595
10. Cryo-EM structure of the botulinum neurotoxin A/SV2B complex and its implications for translocation.  |  Khanppnavar, B., et al. 2025. Nat Commun. 16: 1224. PMID: 39934119

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SV2B Antibody (F-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SV2B Antibody (F-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SV2B Antibody (F-7) Specifications

Alternate Product Name: SV2B

Product Clone Name: F-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-126

Epitope Target: SV2B

Epitope Species: rat

Product Reactivity/Detection: SV2B

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SV2B Antibody (F-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred SV2A antibody is SV2A Antibody (E-8): sc-376234.