survivin Antibody (3F343): sc-73083

Survivin Antibody (3F343) is a mouse monoclonal IgG1 antibody that detects survivin in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Survivin plays a crucial role in regulating cell division and inhibiting apoptosis, making survivin a vital component in cancer biology, as survivin overexpression is often associated with tumor progression and resistance to chemotherapy. Survivin is primarily located in the cytoplasm and nucleus of dividing cells, where survivin associates with the mitotic spindle during cell division, ensuring proper chromosomal segregation. Survivin localization is significant because survivin not only contributes to the survival of cancer cells but also serves as a potential biomarker for cancer diagnosis and prognosis. Additionally, survivin interaction with microtubules is essential for survivin function, as survivin stabilizes the mitotic spindle, and any disruption in this interaction can lead to increased apoptosis and cell death. Anti-survivin antibody (3F343) is an invaluable tool for researchers studying the mechanisms of cancer cell survival and the potential therapeutic targets for cancer treatment.

The preferred survivin antibody is survivin Antibody (D-8): sc-17779.