SULT6B1 Antibody (B-4): sc-398770
- SULT6B1 Antibody (B-4) is a mouse monoclonal IgG1 κ SULT6B1 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 89-106 within an internal region of SULT6B1 of human origin
- SULT6B1 Antibody (B-4) is recommended for detection of SULT6B1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-SULT6B1 Antibody (B-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SULT6B1 Antibody (B-4) for WB applications. These reagents are now offered in bundles with SULT6B1 Antibody (B-4) (see ordering information below).
SULT6B1 Antibody (B-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects SULT6B1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-SULT6B1 antibody (B-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SULT6B1, also known as sulfotransferase family, cytosolic, 6B, member 1, or thyroxine sulfotransferase, is a 303 amino acid cytoplasmic protein predominantly expressed in the kidney and testis, where SULT6B1 plays a crucial role in the metabolism of thyroxine, a key hormone in regulating metabolism, growth, and development. The specific sulfotransferase activity of SULT6B1 towards thyroxine is vital for maintaining hormonal balance and preventing potential metabolic disorders. The gene encoding SULT6B1 spans 28,779 bases and is located on human chromosome 2p22.2, which is significant as chromosome 2 is the second largest human chromosome, containing over 1,400 genes and being associated with various genetic diseases, including Harlequin ichthyosis and Alström syndrome. SULT6B1′s ability to modulate thyroxine levels underscores SULT6B1′s importance in endocrine function and highlights anti-SULT6B1 antibody (B-4)′s relevance in research and clinical applications related to thyroid hormone metabolism.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SULT6B1 Antibody (B-4) References:
- Alstrom syndrome: confirmation of linkage to chromosome 2p12-13 and phenotypic heterogeneity in three affected sibs. | Zumsteg, U., et al. 2000. J Med Genet. 37: E8. PMID: 10882760
- An ATP-binding cassette gene (ABCG5) from the ABCG (White) gene subfamily maps to human chromosome 2p21 in the region of the Sitosterolemia locus. | Shulenin, S., et al. 2001. Cytogenet Cell Genet. 92: 204-8. PMID: 11435688
- Mutation of ALMS1, a large gene with a tandem repeat encoding 47 amino acids, causes Alström syndrome. | Hearn, T., et al. 2002. Nat Genet. 31: 79-83. PMID: 11941370
- Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes. | Freimuth, RR., et al. 2004. Pharmacogenomics J. 4: 54-65. PMID: 14676822
- Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis. | Kelsell, DP., et al. 2005. Am J Hum Genet. 76: 794-803. PMID: 15756637
- Structural and chemical profiling of the human cytosolic sulfotransferases. | Allali-Hassani, A., et al. 2007. PLoS Biol. 5: e97. PMID: 17425406
- Molecular cloning, expression and characterization of a novel mouse SULT6 cytosolic sulfotransferase. | Takahashi, S., et al. 2009. J Biochem. 146: 399-405. PMID: 19505954
- Mapping a gene involved in regulating dietary cholesterol absorption. The sitosterolemia locus is found at chromosome 2p21. | Patel, SB., et al. 1998. J Clin Invest. 102: 1041-4. PMID: 9727073
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SULT6B1 Antibody (B-4) | sc-398770 | 200 µg/ml | $322.00 | |||
SULT6B1 Antibody (B-4): m-IgG Fc BP-HRP Bundle | sc-530922 | 200 µg Ab; 10 µg BP | $361.00 | |||
SULT6B1 Antibody (B-4): m-IgGκ BP-HRP Bundle | sc-524477 | 200 µg Ab, 40 µg BP | $361.00 | |||
SULT6B1 Antibody (B-4): m-IgG1 BP-HRP Bundle | sc-544319 | 200 µg Ab; 20 µg BP | $361.00 | |||
SULT6B1 Antibody (B-4) AC | sc-398770 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SULT6B1 Antibody (B-4) HRP | sc-398770 HRP | 200 µg/ml | $322.00 | |||
SULT6B1 Antibody (B-4) FITC | sc-398770 FITC | 200 µg/ml | $336.00 | |||
SULT6B1 Antibody (B-4) PE | sc-398770 PE | 200 µg/ml | $349.00 | |||
SULT6B1 Antibody (B-4) Alexa Fluor® 488 | sc-398770 AF488 | 200 µg/ml | $364.00 | |||
SULT6B1 Antibody (B-4) Alexa Fluor® 546 | sc-398770 AF546 | 200 µg/ml | $364.00 | |||
SULT6B1 Antibody (B-4) Alexa Fluor® 594 | sc-398770 AF594 | 200 µg/ml | $364.00 | |||
SULT6B1 Antibody (B-4) Alexa Fluor® 647 | sc-398770 AF647 | 200 µg/ml | $364.00 | |||
SULT6B1 Antibody (B-4) Alexa Fluor® 680 | sc-398770 AF680 | 200 µg/ml | $364.00 | |||
SULT6B1 Antibody (B-4) Alexa Fluor® 790 | sc-398770 AF790 | 200 µg/ml | $364.00 | |||
SULT6B1 (B-4) Neutralizing Peptide | sc-398770 P | 100 µg/0.5 ml | $69.00 |