STOP Antibody (D-8): sc-390711

STOP Antibody (D-8) is a mouse monoclonal IgG1 antibody that detects STOP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-STOP antibody (D-8) specifically targets the stable tubule only polypeptide, a crucial neuronal protein that plays a significant role in maintaining microtubule stability under adverse conditions, such as low temperatures or exposure to assembly-inhibiting drugs. STOP is primarily located in the cytoplasm, particularly within the cell body and axons of neurons, where STOP contributes to the formation of cold-stable microtubules. This localization is vital as STOP allows neurons to maintain structural integrity and function even in extreme conditions, thereby supporting neuronal health and resilience. The central region of STOP features five tandem repeats of 46 amino acids, which are essential for stabilizing function, while a SH3-binding motif near the N-terminus facilitates interactions with other proteins, further underscoring STOP′s importance in cellular dynamics. With an ability to withstand temperatures as low as -80° C, STOP is integral to the cellular architecture of neurons, making anti-STOP antibody (D-8) an invaluable tool for researchers studying microtubule dynamics and neuronal stability.

The preferred STOP antibody is STOP Antibody (H-8): sc-137036.