StIP1 Antibody (C-5): sc-393475
- StIP1 Antibody (C-5) is a mouse monoclonal IgG2b κ StIP1 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 532-831 mapping at the C-terminus of StIP1 of mouse origin
- StIP1 Antibody (C-5) is recommended for detection of StIP1 of mouse origin by WB, IP, IF and ELISA
- Anti-StIP1 Antibody (C-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for StIP1 Antibody (C-5) for WB applications. This reagent is now offered in a bundle with StIP1 Antibody (C-5) (see ordering information below).
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SEE ALSO...
StIP1 Antibody (C-5) is a mouse monoclonal IgG2b kappa light chain antibody that detects StIP1 protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). StIP1 (C-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. StIP1 plays a crucial role in regulating Stat3, a member of the signal transducer and activator of transcription (STAT) family, which is involved in numerous biological processes such as nephrogenesis, gliogenesis, hepatogenesis, T cell proliferation, inflammation, and oncogenesis. StIP1 contains 12 WD40 repeats that facilitate protein-protein interactions, particularly with members of the c-Jun N-terminal kinase (JNK) family. Such interaction suggests StIP1 may act as a scaffold protein, enhancing interaction between JNK and Stat3, thereby influencing Stat3 activation and subsequent nuclear translocation. Notably, overexpression of StIP1 has been shown to inhibit Stat3 activation and Stat3-dependent induction of reporter genes, indicating a potential role in modulating cytokine signaling pathways. Given StIP1′s ability to associate with various members of the STAT family, StIP1 may have a broader impact on cytokine signaling events, making StIP1 an important target for research in cellular signaling and disease mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
StIP1 Antibody (C-5) References:
- The WD repeat: a common architecture for diverse functions. | Smith, TF., et al. 1999. Trends Biochem Sci. 24: 181-5. PMID: 10322433
- Mesenchymal to epithelial conversion in rat metanephros is induced by LIF. | Barasch, J., et al. 1999. Cell. 99: 377-86. PMID: 10571180
- Autocrine STIP1 signaling promotes tumor growth and is associated with disease outcome in hepatocellular carcinoma. | Chen, Z., et al. 2017. Biochem Biophys Res Commun. 493: 365-372. PMID: 28887036
- Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction. | Schiattarella, GG., et al. 2021. Nat Commun. 12: 1684. PMID: 33727534
- Parkinson's Disease-Specific Autoantibodies against the Neuroprotective Co-Chaperone STIP1. | Tan, JSY., et al. 2022. Cells. 11: PMID: 35626686
- Phosphorylated SHMT2 Regulates Oncogenesis Through m6A Modification in Lung Adenocarcinoma. | Han, T., et al. 2024. Adv Sci (Weinh). 11: e2307834. PMID: 38460155
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
StIP1 Antibody (C-5) | sc-393475 | 200 µg/ml | $322.00 | |||
StIP1 Antibody (C-5): m-IgG Fc BP-HRP Bundle | sc-526256 | 200 µg Ab; 10 µg BP | $361.00 | |||
StIP1 Antibody (C-5) AC | sc-393475 AC | 500 µg/ml, 25% agarose | $424.00 | |||
StIP1 Antibody (C-5) HRP | sc-393475 HRP | 200 µg/ml | $322.00 | |||
StIP1 Antibody (C-5) FITC | sc-393475 FITC | 200 µg/ml | $336.00 | |||
StIP1 Antibody (C-5) PE | sc-393475 PE | 200 µg/ml | $349.00 | |||
StIP1 Antibody (C-5) Alexa Fluor® 488 | sc-393475 AF488 | 200 µg/ml | $364.00 | |||
StIP1 Antibody (C-5) Alexa Fluor® 546 | sc-393475 AF546 | 200 µg/ml | $364.00 | |||
StIP1 Antibody (C-5) Alexa Fluor® 594 | sc-393475 AF594 | 200 µg/ml | $364.00 | |||
StIP1 Antibody (C-5) Alexa Fluor® 647 | sc-393475 AF647 | 200 µg/ml | $364.00 | |||
StIP1 Antibody (C-5) Alexa Fluor® 680 | sc-393475 AF680 | 200 µg/ml | $364.00 | |||
StIP1 Antibody (C-5) Alexa Fluor® 790 | sc-393475 AF790 | 200 µg/ml | $364.00 |