Stim1 Antibody (CDN3H4): sc-66173

Stim1 Antibody (CDN3H4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Stim1 in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP). Anti-Stim1 antibody (CDN3H4) is available in a non-conjugated form, providing researchers with a versatile tool for studying this critical protein. Stim1, or stromal interaction molecule 1, is a vital transmembrane glycoprotein located in the endoplasmic reticulum (ER), where Stim1 functions as a calcium sensor. Stim1′s ability to detect changes in intracellular calcium levels is crucial for various cellular processes, including secretion and gene transcription. Upon depletion of calcium stores, Stim1 undergoes significant conformational changes that enable translocation to the plasma membrane, where Stim1 activates the calcium release-activated calcium (CRAC) channel subunit, TMEM142A/Orai1. This mechanism is essential for maintaining cellular calcium homeostasis and facilitating calcium influx, which is necessary for numerous physiological functions. Additionally, Stim1′s interaction with Stim2, a known inhibitor of Stim1-mediated store-operated calcium entry, highlights Stim1′s regulatory role in calcium signaling pathways. The implications of Stim1 extend to tumor growth suppression and the interactions between stromal and hematopoietic cells, making Stim1 a significant focus of research in cancer biology and cellular signaling.

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Stim1 Antibody (CDN3H4) References:

1. STIM1 (c)AMPs up melanogenesis.  |  Soboloff, J., et al. 2018. EMBO J. 37: PMID: 29449324
2. Role of STIM1 in neurodegeneration.  |  Pascual-Caro, C., et al. 2018. World J Biol Chem. 9: 16-24. PMID: 30568747
3. STIM1 structure-function and downstream signaling pathways.  |  Soboloff, J. and Romanin, C. 2019. Cell Calcium. 80: 101-102. PMID: 30999215
4. STIM1 is a metabolic checkpoint regulating the invasion and metastasis of hepatocellular carcinoma.  |  Zhao, H., et al. 2020. Theranostics. 10: 6483-6499. PMID: 32483465
5. STIM1 Mediates Calcium-Dependent Epigenetic Reprogramming in Pancreatic Cancer.  |  Kutschat, AP., et al. 2021. Cancer Res. 81: 2943-2955. PMID: 33436389
6. The roles and mechanism of STIM1 in tumorigenesis and metastasis.  |  Yan, CH., et al. 2023. Yi Chuan. 45: 395-408. PMID: 37194587
7. TSPAN18 facilitates bone metastasis of prostate cancer by protecting STIM1 from TRIM32-mediated ubiquitination.  |  Zhou, Q., et al. 2023. J Exp Clin Cancer Res. 42: 195. PMID: 37542345
8. STIM1 translocation to the nucleus protects cells from DNA damage.  |  Sanchez-Lopez, I., et al. 2024. Nucleic Acids Res. 52: 2389-2415. PMID: 38224453
9. Vanillic acid restores homeostasis of intestinal epithelium in colitis through inhibiting CA9/STIM1-mediated ferroptosis.  |  Ni, J., et al. 2024. Pharmacol Res. 202: 107128. PMID: 38438089
10. STIM1 promotes acquired resistance to sorafenib by attenuating ferroptosis in hepatocellular carcinoma.  |  Ren, R., et al. 2024. Genes Dis. 11: 101281. PMID: 39281833

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Stim1 Antibody (CDN3H4) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-Stim1 Antibody (CDN3H4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Stim1 Antibody (CDN3H4) Specifications

Alternate Product Name: Stromal interaction molecule 1

Product Clone Name: CDN3H4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Stim1

Epitope Species: mouse

Product Reactivity/Detection: Stim1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for Stim1 Antibody (CDN3H4): N/A

The preferred Stim1 antibody is Stim1 Antibody (A-8): sc-166840.