Stat3 Antibody (285.87): sc-293151

Stat3 Antibody (285.87) is a mouse monoclonal IgG1 antibody that detects Stat3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Stat3 monoclonal antibody (285.87) is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. Stat3 plays a crucial role in mediating cellular responses to a variety of extracellular signals, particularly in the context of cytokine and growth factor signaling. Upon activation, Stat3 translocates to the nucleus where Stat3 regulates the expression of genes involved in cell proliferation, survival, and differentiation, making Stat3 a key player in processes such as immune response and oncogenesis. Notably, Stat3 is subject to various post-translational modifications, including phosphorylation and acetylation, which can significantly influence activity and stability. For instance, tyrosine phosphorylation at specific residues is essential for dimerization and subsequent nuclear translocation, while acetylation can modulate transcriptional activity. Understanding these modifications is vital, as dysregulation of Stat3 activity is implicated in numerous diseases, including cancer, where aberrant signaling can lead to uncontrolled cell growth and resistance to apoptosis. Anti-Stat3 antibody (285.87) provides a reliable tool for exploring the intricate regulatory mechanisms of Stat3 and involvement in critical cellular processes and disease states.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Stat3 Antibody (285.87) has 30 citations in a variety of scientific publications.

Primary antibodies like Anti-Stat3 Antibody (285.87) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Stat3 Antibody (285.87) Specifications

Alternate Product Name: Stat3

Product Clone Name: 285.87

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ lambda light chain

Amino Acids: 1-175

Epitope Target: Stat3

Epitope Species: human

Product Reactivity/Detection: Stat3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 30 citations in various scientific publications

Available Conjugates/Forms for Stat3 Antibody (285.87): AC: Agarose, HRP: Horseradish Peroxidase

The preferred p-Stat3 antibody is p-Stat3 Antibody (B-7): sc-8059.