Stat2 Antibody (A-7): sc-1668
- Stat2 Antibody (A-7) is a mouse monoclonal IgG1 κ, cited in 54 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 832-851 at the C-terminus of Stat2 of human origin
- Stat2 Antibody (A-7) is recommended for detection of Stat2 p113 of human origin by WB, IP, IF and ELISA
- Anti-Stat2 Antibody (A-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for Gel Supershift and ChIP applications (sc-1668 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Stat2 Antibody (A-7) for WB applications. These reagents are now offered in bundles with Stat2 Antibody (A-7) (see ordering information below).
Stat2 Antibody (A-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects Stat2 protein of human origin through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Stat2 (A-7) antibody is offered in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates. Stat2 protein plays a crucial role in signaling pathways activated by interferons and growth factors, particularly in formation of ISGF3 transcription factor complex alongside Stat1. ISGF3 complex is essential for mediating transcriptional response to interferons, which are vital for immune response against viral infections and for regulating cell growth and differentiation. Stat2 forms heterodimers with Stat1 to enhance specificity and efficacy of signaling cascade, underscoring importance in immune regulation and cellular communication. Stat2 (A-7) monoclonal antibody enables valuable insights into mechanisms of immune signaling and role of transcription factors in cellular responses.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Stat2 Antibody (A-7) References:
- Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase. | Elliott, J., et al. 2007. J Virol. 81: 3428-36. PMID: 17251292
- Stat2-Drp1 mediated mitochondrial mass increase is necessary for pro-inflammatory differentiation of macrophages. | Yu, W., et al. 2020. Redox Biol. 37: 101761. PMID: 33080440
- The Fibrillin-1/VEGFR2/STAT2 signaling axis promotes chemoresistance via modulating glycolysis and angiogenesis in ovarian cancer organoids and cells. | Wang, Z., et al. 2022. Cancer Commun (Lond). 42: 245-265. PMID: 35234370
- IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling. | Chiriac, MT., et al. 2024. Gut. 73: 282-297. PMID: 37884352
- Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3. | Qureshi, SA., et al. 1995. Proc Natl Acad Sci U S A. 92: 3829-33. PMID: 7537377
- Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3. | Schaefer, TS., et al. 1995. Proc Natl Acad Sci U S A. 92: 9097-101. PMID: 7568080
- Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. | Schindler, C. and Darnell, JE. 1995. Annu Rev Biochem. 64: 621-51. PMID: 7574495
- Interleukin-3, erythropoietin, and prolactin activate a STAT5-like factor in lymphoid cells. | Pallard, C., et al. 1995. J Biol Chem. 270: 15942-5. PMID: 7608147
- Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation. | Yamamoto, K., et al. 1994. Mol Cell Biol. 14: 4342-9. PMID: 8007943
- An interleukin-4-induced transcription factor: IL-4 Stat. | Hou, J., et al. 1994. Science. 265: 1701-6. PMID: 8085155
- Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. | Zhong, Z., et al. 1994. Science. 264: 95-8. PMID: 8140422
- Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. | Darnell, JE., et al. 1994. Science. 264: 1415-21. PMID: 8197455
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Stat2 Antibody (A-7) | sc-1668 | 200 µg/ml | $322.00 | |||
Stat2 Antibody (A-7): m-IgG Fc BP-HRP Bundle | sc-528132 | 200 µg Ab; 10 µg BP | $361.00 | |||
Stat2 Antibody (A-7): m-IgGκ BP-HRP Bundle | sc-520436 | 200 µg Ab, 40 µg BP | $361.00 | |||
Stat2 Antibody (A-7) X | sc-1668 X | 200 µg/0.1 ml | $322.00 | |||
Stat2 Antibody (A-7) AC | sc-1668 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Stat2 Antibody (A-7) HRP | sc-1668 HRP | 200 µg/ml | $322.00 | |||
Stat2 Antibody (A-7) FITC | sc-1668 FITC | 200 µg/ml | $336.00 | |||
Stat2 Antibody (A-7) PE | sc-1668 PE | 200 µg/ml | $349.00 | |||
Stat2 Antibody (A-7) Alexa Fluor® 488 | sc-1668 AF488 | 200 µg/ml | $364.00 | |||
Stat2 Antibody (A-7) Alexa Fluor® 546 | sc-1668 AF546 | 200 µg/ml | $364.00 | |||
Stat2 Antibody (A-7) Alexa Fluor® 594 | sc-1668 AF594 | 200 µg/ml | $364.00 | |||
Stat2 Antibody (A-7) Alexa Fluor® 647 | sc-1668 AF647 | 200 µg/ml | $364.00 | |||
Stat2 Antibody (A-7) Alexa Fluor® 680 | sc-1668 AF680 | 200 µg/ml | $364.00 | |||
Stat2 Antibody (A-7) Alexa Fluor® 790 | sc-1668 AF790 | 200 µg/ml | $364.00 | |||
Stat2 (A-7) Neutralizing Peptide | sc-1668 P | 100 µg/0.5 ml | $69.00 |