Stat1 Antibody (6D776): sc-73070
- Stat1 Antibody (6D776) is a mouse monoclonal IgG1, cited in 6 publications, provided at 100 µg/ml
- raised against human STAT 1 peptide sequence 8-23 (QLDSKFLEQVHQLYD)
- recommended for detection of Stat1 of mouse, rat and human origin by WB and IP
- See Stat1 (C-136): sc-464 for Stat1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Stat1 Antibody (6D776). This work is in progress.
Stat1 Antibody (6D776) is a mouse monoclonal IgG1 antibody that detects Stat1 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Stat1 plays a crucial role in mediating cellular responses to interferons, which are vital for the immune response and antiviral defense. Upon activation by interferon-α, Stat1 forms a heterodimer with Stat2, contributing to the formation of the ISGF3 transcription factor complex that regulates the expression of genes involved in immune responses and cell growth. The proper functioning of Stat1 is essential, as dysregulation can lead to immune deficiencies or increased susceptibility to infections. Additionally, Stat1 undergoes post-translational modifications, including phosphorylation, which is critical for activation and subsequent nuclear translocation. This modification not only enhances transcriptional activity but also influences interaction with other proteins, thereby modulating various signaling pathways. Anti-Stat1 antibody (6D776) is an invaluable tool for researchers studying the intricate mechanisms of immune signaling and the role of Stat1 in various biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Stat1 Antibody (6D776) References:
- Transcription protein STAT1: biology and relation to cancer. | Adámková, L., et al. 2007. Folia Biol (Praha). 53: 1-6. PMID: 17328836
- STAT1 drives tumor progression in serous papillary endometrial cancer. | Kharma, B., et al. 2014. Cancer Res. 74: 6519-30. PMID: 25267067
- STAT1 single nucleotide polymorphisms and susceptibility to immune thrombocytopenia. | Chen, Z., et al. 2015. Autoimmunity. 48: 305-12. PMID: 25707685
- STAT1 inhibitor alleviates spinal cord injury by decreasing apoptosis. | Wu, YX., et al. 2016. Genet Mol Res. 15: PMID: 27051009
- STAT1 Gain-of-Function Mutations Cause High Total STAT1 Levels With Normal Dephosphorylation. | Zimmerman, O., et al. 2019. Front Immunol. 10: 1433. PMID: 31354696
- PHLPP1 counter-regulates STAT1-mediated inflammatory signaling. | Cohen Katsenelson, K., et al. 2019. Elife. 8: PMID: 31408005
- STAT1 determines aggressiveness of glioblastoma both in vivo and in vitro through wnt/β-catenin signalling pathway. | Zhao, L., et al. 2020. Cell Biochem Funct. 38: 630-641. PMID: 32390230
- Expression of STAT1 is positively correlated with PD-L1 in human ovarian cancer. | Liu, F., et al. 2020. Cancer Biol Ther. 21: 963-971. PMID: 33043814
- STAT1 Is Required for Decreasing Accumulation of Granulocytic Cells via IL-17 during Initial Steps of Colitis-Associated Cancer. | Delgado-Ramirez, Y., et al. 2021. Int J Mol Sci. 22: PMID: 34299314
- Inhibition of CDKL3 downregulates STAT1 thus suppressing prostate cancer development. | Jiang, Q., et al. 2023. Cell Death Dis. 14: 189. PMID: 36899018
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Stat1 Antibody (6D776) | sc-73070 | 100 µg/ml | $322.00 |