StARD8 Antibody (E-2): sc-166725
- StARD8 Antibody (E-2) is a mouse monoclonal IgG1 κ StARD8 antibody, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 731-830 mapping within an internal region of StARD8 of human origin
- StARD8 Antibody (E-2) is recommended for detection of StARD8 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-StARD8 Antibody (E-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for StARD8 Antibody (E-2) for WB applications. These reagents are now offered in bundles with StARD8 Antibody (E-2) (see ordering information below).
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StARD8 Antibody (E-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects StARD8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). StARD8 (E-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. StARD8 protein, also known as deleted in liver cancer protein 3 (DLC3) or STARTGAP3, is a member of the steroidogenic acute regulatory protein-related lipid transfer (START) domain family, which consists of fifteen proteins that share a characteristic START domain and are involved in lipid metabolism and transport. StARD8 is specifically classified within the RhoGAP START group, alongside StARD12 and StARD13, and functions as a RhoGAP protein that interacts with Rho A and Cdc42. StARD8 protein is primarily localized to focal adhesions and features a RhoGAP domain, a sterile alpha motif (SAM) domain, and a START domain, which are crucial for cellular signaling pathways. StARD8 functions as a tumor suppressor; studies have shown that overexpression of StARD8 in various cancer cell lines leads to repression of cell proliferation and colony formation, highlighting StARD8′s potential role in regulating cell growth and implications in cancer biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
StARD8 Antibody (E-2) References:
- Characterization of human ARHGAP10 gene in silico. | Katoh, M. and Katoh, M. 2004. Int J Oncol. 25: 1201-6. PMID: 15375573
- Mitochondrial targeting of growth suppressor protein DLC2 through the START domain. | Ng, DC., et al. 2006. FEBS Lett. 580: 191-8. PMID: 16364308
- The consensus coding sequences of human breast and colorectal cancers. | Sjöblom, T., et al. 2006. Science. 314: 268-74. PMID: 16959974
- Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors. | Ullmannova, V. and Popescu, NC. 2006. Int J Oncol. 29: 1127-32. PMID: 17016643
- Deleted in liver cancer 3 (DLC-3), a novel Rho GTPase-activating protein, is downregulated in cancer and inhibits tumor cell growth. | Durkin, ME., et al. 2007. Oncogene. 26: 4580-9. PMID: 17297465
- Solution structures, dynamics, and lipid-binding of the sterile alpha-motif domain of the deleted in liver cancer 2. | Li, H., et al. 2007. Proteins. 67: 1154-66. PMID: 17380510
- Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities. | Qian, X., et al. 2007. Proc Natl Acad Sci U S A. 104: 9012-7. PMID: 17517630
- The NMR structure of the murine DLC2 SAM domain reveals a variant fold that is similar to a four-helix bundle. | Kwan, JJ. and Donaldson, LW. 2007. BMC Struct Biol. 7: 34. PMID: 17519008
- START-GAP3/DLC3 is a GAP for RhoA and Cdc42 and is localized in focal adhesions regulating cell morphology. | Kawai, K., et al. 2007. Biochem Biophys Res Commun. 364: 783-9. PMID: 17976533
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
StARD8 Antibody (E-2) | sc-166725 | 200 µg/ml | $322.00 | |||
StARD8 Antibody (E-2): m-IgG Fc BP-HRP Bundle | sc-527178 | 200 µg Ab; 10 µg BP | $361.00 | |||
StARD8 Antibody (E-2): m-IgG1 BP-HRP Bundle | sc-532551 | 200 µg Ab; 20 µg BP | $361.00 | |||
StARD8 Antibody (E-2) AC | sc-166725 AC | 500 µg/ml, 25% agarose | $424.00 | |||
StARD8 Antibody (E-2) HRP | sc-166725 HRP | 200 µg/ml | $322.00 | |||
StARD8 Antibody (E-2) FITC | sc-166725 FITC | 200 µg/ml | $336.00 | |||
StARD8 Antibody (E-2) PE | sc-166725 PE | 200 µg/ml | $349.00 | |||
StARD8 Antibody (E-2) Alexa Fluor® 488 | sc-166725 AF488 | 200 µg/ml | $364.00 | |||
StARD8 Antibody (E-2) Alexa Fluor® 546 | sc-166725 AF546 | 200 µg/ml | $364.00 | |||
StARD8 Antibody (E-2) Alexa Fluor® 594 | sc-166725 AF594 | 200 µg/ml | $364.00 | |||
StARD8 Antibody (E-2) Alexa Fluor® 647 | sc-166725 AF647 | 200 µg/ml | $364.00 | |||
StARD8 Antibody (E-2) Alexa Fluor® 680 | sc-166725 AF680 | 200 µg/ml | $364.00 | |||
StARD8 Antibody (E-2) Alexa Fluor® 790 | sc-166725 AF790 | 200 µg/ml | $364.00 |