StARD8 Activators
StARD8 activators primarily function through pathways that modulate the phosphorylation state of StARD8. Compounds such as 8-Br-cAMP, Forskolin, IBMX, Rolipram, Cilostazol, H-89, Vardenafil, Sildenafil, Tadalafil, and Papaverine all work by increasing intracellular cAMP levels through various mechanisms. cAMP is a second messenger that activates protein kinase A (PKA). PKA can phosphorylate and activate StARD8, leading to an increase in its functional activity. By increasing the levels of cAMP in the cell, these compounds indirectly lead to the activation of StARD8.
On the other hand, Y-27632 and Fasudil act by inhibiting Rho-associated protein kinases (ROCK1/2). ROCK1/2 are known to phosphorylate and inactivate StARD8. Therefore, inhibition of these kinases leads to reduced phosphorylation and inactivation of StARD8, thereby enhancing its activity. Y-27632 and Fasudil are thus indirect activators of StARD8. In summary, the compounds listed either enhance the activity of StARD8 by triggering its activation through the cAMP-PKA pathway or by preventing its inactivation through the ROCK pathway.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Br-cAMP is a cell-permeable cAMP analog. It activates protein kinase A (PKA), which then phosphorylates and activates StARD8. This leads to enhanced StARD8 activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a labdane diterpene that activates adenylate cyclase, increasing intracellular cAMP levels. Elevated cAMP triggers PKA activation, which in turn activates StARD8. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor. By inhibiting phosphodiesterases, IBMX prevents the breakdown of cAMP, leading to an increase in intracellular cAMP levels. This triggers PKA activation and subsequently activates StARD8. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective phosphodiesterase 4 inhibitor. It prevents the breakdown of cAMP, leading to increased intracellular cAMP. This activates PKA, which phosphorylates and activates StARD8. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a selective inhibitor of ROCK1 and ROCK2. By inhibiting ROCK1/2, it prevents the phosphorylation and inactivation of StARD8, leading to enhanced StARD8 activity. | ||||||
Fasudil, Monohydrochloride Salt | 105628-07-7 | sc-203418 sc-203418A sc-203418B sc-203418C sc-203418D sc-203418E sc-203418F | 10 mg 50 mg 250 mg 1 g 2 g 5 g 10 g | $18.00 $32.00 $85.00 $165.00 $248.00 $486.00 $910.00 | 5 | |
Fasudil is a potent Rho-kinase inhibitor. By inhibiting Rho-kinase, it prevents the phosphorylation and inactivation of StARD8, enhancing StARD8 activity. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $107.00 $316.00 | 3 | |
Cilostazol is a phosphodiesterase 3 inhibitor. It prevents the breakdown of cAMP, resulting in increased intracellular cAMP levels. This leads to PKA activation, which in turn activates StARD8. | ||||||
Vardenafil | 224785-90-4 | sc-362054 sc-362054A sc-362054B | 100 mg 1 g 50 g | $516.00 $720.00 $16326.00 | 7 | |
Vardenafil is a phosphodiesterase 5 inhibitor. It prevents the breakdown of cAMP, leading to increased intracellular cAMP levels. This activates PKA, which phosphorylates and activates StARD8. | ||||||
Tadalafil | 171596-29-5 | sc-208412 | 50 mg | $176.00 | 13 | |
Tadalafil is a phosphodiesterase 5 inhibitor. It prevents the breakdown of cAMP, leading to increased intracellular cAMP levels. This activates PKA, which phosphorylates and activates StARD8. | ||||||
Papaverine | 58-74-2 | sc-279951 sc-279951A sc-279951B | 10 mg 50 mg 100 mg | $153.00 $265.00 $459.00 | ||
Papaverine is a phosphodiesterase inhibitor. By inhibiting phosphodiesterases, it prevents the breakdown of cAMP, leading to increased intracellular cAMP levels. This triggers PKA activation, which phosphorylates and activates StARD8. | ||||||