STAM Antibody (D-3): sc-133092
- STAM Antibody (D-3) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 366-540 mapping at the C-terminus of STAM of human origin
- recommended for detection of STAM of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2a BP-HRP is the preferred secondary detection reagent for STAM Antibody (D-3) for WB applications. This reagent is now offered in a bundle with STAM Antibody (D-3) (see ordering information below).
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STAM Antibody (D-3) is a mouse monoclonal IgG2a antibody that detects STAM in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). STAM, or signal transducing adapter molecule, plays a crucial role in the signaling pathways activated by various cytokines, particularly in the context of immune responses. STAM is primarily located in the cytoplasm, where STAM acts as a mediator in the signaling cascade initiated by the interleukin-2 receptor. This localization is significant because STAM interacts with key signaling molecules such as JAK2 and JAK3, facilitating the downstream activation of transcription factors like c-Myc and c-Fos, which are essential for cell proliferation and differentiation. STAM′s ability to undergo tyrosine phosphorylation upon cytokine stimulation further underscores STAM′s importance in modulating cellular responses, making STAM a vital component in the regulation of immune functions. Anti-STAM antibody (D-3) is an invaluable tool for researchers studying cytokine signaling and its implications in various biological processes and diseases.
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STAM Antibody (D-3) References:
- STAM/EAST/Hbp adapter proteins--integrators of signalling pathways. | Lohi, O. and Lehto, VP. 2001. FEBS Lett. 508: 287-90. PMID: 11728436
- The Hrs/STAM complex in the downregulation of receptor tyrosine kinases. | Komada, M. and Kitamura, N. 2005. J Biochem. 137: 1-8. PMID: 15713877
- STAM-AMSH interaction facilitates the deubiquitination activity in the C-terminal AMSH. | Kim, MS., et al. 2006. Biochem Biophys Res Commun. 351: 612-8. PMID: 17078930
- The Vps27/Hrs/STAM (VHS) Domain of the Signal-transducing Adaptor Molecule (STAM) Directs Associated Molecule with the SH3 Domain of STAM (AMSH) Specificity to Longer Ubiquitin Chains and Dictates the Position of Cleavage. | Baiady, N., et al. 2016. J Biol Chem. 291: 2033-2042. PMID: 26601948
- STAM-binding protein regulates melanoma metastasis through SLUG stabilization. | Iwakami, Y., et al. 2018. Biochem Biophys Res Commun. 507: 484-488. PMID: 30454887
- STAM binding protein regulated by hsa_circ_0007334 exerts oncogenic potential in pancreatic cancer. | Yu, S., et al. 2022. Pancreatology. 22: 1003-1012. PMID: 36089485
- STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK-STAT endosomal activation. | Zanin, N., et al. 2023. Nat Cell Biol. 25: 425-438. PMID: 36797476
- STAM transports STING oligomers into extracellular vesicles, down-regulating the innate immune response. | Liang, J. and Yin, H. 2023. J Extracell Vesicles. 12: e12316. PMID: 36946680
- Identification of STAM-binding protein as a target for the treatment of gemcitabine resistance pancreatic cancer in a nutrient-poor microenvironment. | Zhang, W., et al. 2024. Cell Death Dis. 15: 657. PMID: 39242557
- STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction. | Takeshita, T., et al. 1997. Immunity. 6: 449-57. PMID: 9133424
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
STAM Antibody (D-3) | sc-133092 | 200 µg/ml | $322.00 | |||
STAM Antibody (D-3): m-IgG2a BP-HRP Bundle | sc-546021 | 200 µg Ab; 10 µg BP | $361.00 |