SRp30c Antibody (1G7): sc-293314

SRp30c Antibody (1G7) is a mouse monoclonal IgG2a kappa light chain antibody that detects SRp30c protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SRp30c antibody (1G7) is available as the non-conjugated form. SRp30c protein, also known as SFRS9 (splicing factor, arginine/serine-rich 9), plays a crucial role in the regulation of pre-mRNA splicing, which is essential for accurate gene expression. This 221 amino acid protein is primarily located in the nucleus, where SRp30c interacts with various splicing factors and RNA sequences to enhance the recognition of weak splice sites, thereby influencing alternative splicing events. The presence of two RNA recognition motifs (RRM) and an arginine/serine (RS)-rich domain in SRp30c structure allows binding to specific RNA sequences, facilitating spliceosome assembly and ensuring proper mRNA maturation. High expression levels of SRp30c in tissues such as the placenta, heart, pancreas, and kidney underscore SRp30c importance in cellular processes and development. Using SRp30c monoclonal antibody (1G7) in research can provide valuable insights into splicing regulation mechanisms and their implications in various biological contexts.

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SRp30c Antibody (1G7) References:

1. Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c.  |  Stoss, O., et al. 1999. J Biol Chem. 274: 10951-62. PMID: 10196175
2. Htra2-beta 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2).  |  Hofmann, Y., et al. 2000. Proc Natl Acad Sci U S A. 97: 9618-23. PMID: 10931943
3. SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1.  |  Young, PJ., et al. 2002. Hum Mol Genet. 11: 577-87. PMID: 11875052
4. Bombesin attenuates pre-mRNA splicing of glucocorticoid receptor by regulating the expression of serine-arginine protein p30c (SRp30c) in prostate cancer cells.  |  Zhu, J., et al. 2007. Biochim Biophys Acta. 1773: 1087-94. PMID: 17540466
5. hnRNP I/PTB can antagonize the splicing repressor activity of SRp30c.  |  Paradis, C., et al. 2007. RNA. 13: 1287-300. PMID: 17548433
6. Antagonistic effects of the SRp30c protein and cryptic 5' splice sites on the alternative splicing of the apoptotic regulator Bcl-x.  |  Cloutier, P., et al. 2008. J Biol Chem. 283: 21315-24. PMID: 18534987
7. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors.  |  Screaton, GR., et al. 1995. EMBO J. 14: 4336-49. PMID: 7556075

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SRp30c Antibody (1G7) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-SRp30c Antibody (1G7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SRp30c Antibody (1G7) Specifications

Alternate Product Name: SRp30c

Product Clone Name: 1G7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-100

Epitope Target: SRp30c

Epitope Species: human

Product Reactivity/Detection: SRp30c

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for SRp30c Antibody (1G7): N/A