SRm160 Antibody (E-8): sc-398789

SRm160 Antibody (E-8) is a mouse monoclonal IgM antibody that detects SRm160 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SRm160 antibody (E-8) is available as the non-conjugated form. SRm160 protein plays a crucial role in the regulation of pre-mRNA splicing, functioning as a splicing coactivator that enhances interactions between various splicing factors bound to pre-mRNA. Located predominantly in the nucleus, SRm160 is essential for spliceosome assembly, a complex responsible for precise removal of introns from pre-mRNA. This localization ensures splicing occurs in appropriate cellular compartments, allowing efficient processing of mRNA before translation into proteins. SRm160 protein interacts with core small nuclear ribonucleoprotein particles (snRNPs) and other serine/arginine-rich splicing factors, facilitating splice site recognition and regulation of alternative splicing patterns. SRm160 (E-8) antibody provides valuable insights into mechanisms of gene expression regulation and intricate processes governing mRNA maturation.

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SRm160 Antibody (E-8) References:

1. Selection and characterization of pre-mRNA splicing enhancers: identification of novel SR protein-specific enhancer sequences.  |  Schaal, TD. and Maniatis, T. 1999. Mol Cell Biol. 19: 1705-19. PMID: 10022858
2. The SRm160/300 splicing coactivator is required for exon-enhancer function.  |  Eldridge, AG., et al. 1999. Proc Natl Acad Sci U S A. 96: 6125-30. PMID: 10339552
3. The SRm160/300 splicing coactivator subunits.  |  Blencowe, BJ., et al. 2000. RNA. 6: 111-20. PMID: 10668804
4. Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases.  |  Blencowe, BJ. 2000. Trends Biochem Sci. 25: 106-10. PMID: 10694877
5. Specific commitment of different pre-mRNAs to splicing by single SR proteins.  |  Fu, XD. 1993. Nature. 365: 82-5. PMID: 8361546
6. Identification and characterisation of a novel human RNA-binding protein.  |  Badolato, J., et al. 1995. Gene. 166: 323-7. PMID: 8543184
7. A coactivator of pre-mRNA splicing.  |  Blencowe, BJ., et al. 1998. Genes Dev. 12: 996-1009. PMID: 9531537

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SRm160 Antibody (E-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SRm160 Antibody (E-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SRm160 Antibody (E-8) Specifications

Alternate Product Name: SRm160

Product Clone Name: E-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 654-676

Epitope Target: SRm160

Epitope Species: human

Product Reactivity/Detection: SRm160

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SRm160 Antibody (E-8): P: Blocking Peptide