SRCRB4D Antibody (A-10): sc-515760
- SRCRB4D Antibody (A-10) is a mouse monoclonal IgG1 κ SRCRB4D antibody provided at 200 µg/ml
- raised against amino acids 527-577 mapping near the C-terminus of SRCRB4D of mouse origin
- SRCRB4D Antibody (A-10) is recommended for detection of SRCRB4D of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-SRCRB4D Antibody (A-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SRCRB4D Antibody (A-10) for WB applications. These reagents are now offered in bundles with SRCRB4D Antibody (A-10) (see ordering information below).
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SRCRB4D Antibody (A-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects SRCRB4D protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SRCRB4D (A-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SRCRB4D protein, also known as scavenger receptor cysteine-rich domain containing, group B (4 domains), is a 575 amino acid member of the scavenger receptor cysteine-rich superfamily, which plays a crucial role in immune system development and regulation. SRCRB4D protein is primarily located on the cell surface and is secreted, where SRCRB4D mediates endocytosis and degradation of chemically modified low-density lipoproteins, such as acetylated LDL and oxidized LDL. SRCRB4D presence in various tissues underscores its importance in innate and adaptive immune responses, as SRCRB4D helps clear modified lipoproteins that can contribute to atherosclerosis and other inflammatory conditions. Notably, SRCRB4D contains four highly conserved SRCR domains characterized by a unique intradomain disulfide-bond pattern formed by eight evenly spaced cysteines, which is essential for structural integrity and functional interactions. anti-SRCRB4D antibody (A-10) serves as an invaluable tool for researchers studying lipid metabolism and immune response mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SRCRB4D Antibody (A-10) References:
- Crystal structure of a scavenger receptor cysteine-rich domain sheds light on an ancient superfamily. | Hohenester, E., et al. 1999. Nat Struct Biol. 6: 228-32. PMID: 10074941
- Dynamic expression of multiple scavenger receptor cysteine-rich genes in coelomocytes of the purple sea urchin. | Pancer, Z. 2000. Proc Natl Acad Sci U S A. 97: 13156-61. PMID: 11069281
- Cloning of S4D-SRCRB, a new soluble member of the group B scavenger receptor cysteine-rich family (SRCR-SF) mapping to human chromosome 7q11.23. | Padilla, O., et al. 2002. Immunogenetics. 54: 621-34. PMID: 12466895
- The Scavenger Receptor Cysteine-Rich (SRCR) domain: an ancient and highly conserved protein module of the innate immune system. | Sarrias, MR., et al. 2004. Crit Rev Immunol. 24: 1-37. PMID: 14995912
- Crystal structure of the third extracellular domain of CD5 reveals the fold of a group B scavenger cysteine-rich receptor domain. | Rodamilans, B., et al. 2007. J Biol Chem. 282: 12669-77. PMID: 17322294
- Salivary agglutinin/glycoprotein-340/DMBT1: a single molecule with variable composition and with different functions in infection, inflammation and cancer. | Ligtenberg, AJ., et al. 2007. Biol Chem. 388: 1275-89. PMID: 18020944
- The SRCR superfamily: a family reminiscent of the Ig superfamily. | Resnick, D., et al. 1994. Trends Biochem Sci. 19: 5-8. PMID: 8140623
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SRCRB4D Antibody (A-10) | sc-515760 | 200 µg/ml | $322.00 | |||
SRCRB4D Antibody (A-10): m-IgG Fc BP-HRP Bundle | sc-531503 | 200 µg Ab; 10 µg BP | $361.00 | |||
SRCRB4D Antibody (A-10): m-IgGκ BP-HRP Bundle | sc-525203 | 200 µg Ab, 40 µg BP | $361.00 | |||
SRCRB4D Antibody (A-10): m-IgG1 BP-HRP Bundle | sc-544596 | 200 µg Ab; 20 µg BP | $361.00 | |||
SRCRB4D Antibody (A-10) AC | sc-515760 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SRCRB4D Antibody (A-10) HRP | sc-515760 HRP | 200 µg/ml | $322.00 | |||
SRCRB4D Antibody (A-10) FITC | sc-515760 FITC | 200 µg/ml | $336.00 | |||
SRCRB4D Antibody (A-10) PE | sc-515760 PE | 200 µg/ml | $349.00 | |||
SRCRB4D Antibody (A-10) Alexa Fluor® 488 | sc-515760 AF488 | 200 µg/ml | $364.00 | |||
SRCRB4D Antibody (A-10) Alexa Fluor® 546 | sc-515760 AF546 | 200 µg/ml | $364.00 | |||
SRCRB4D Antibody (A-10) Alexa Fluor® 594 | sc-515760 AF594 | 200 µg/ml | $364.00 | |||
SRCRB4D Antibody (A-10) Alexa Fluor® 647 | sc-515760 AF647 | 200 µg/ml | $364.00 | |||
SRCRB4D Antibody (A-10) Alexa Fluor® 680 | sc-515760 AF680 | 200 µg/ml | $364.00 | |||
SRCRB4D Antibody (A-10) Alexa Fluor® 790 | sc-515760 AF790 | 200 µg/ml | $364.00 |