SRC-1 Antibody (6D775): sc-73057

SRC-1 Antibody (6D775) is a mouse monoclonal IgG1 antibody that detects SRC-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. SRC-1, also known as steroid receptor coactivator-1, plays a crucial role in gene expression regulation by acting as a coactivator for steroid hormone receptors, enhancing transcriptional activity. SRC-1 is primarily located in the nucleus, where SRC-1 interacts with various transcription factors to modulate target gene expression involved in metabolism, reproduction, and cell growth. Nuclear localization of SRC-1 enables direct interaction with hormone-bound receptors and transcriptional machinery, facilitating precise gene expression regulation in response to hormonal signals. SRC-1 undergoes post-translational modifications, including phosphorylation and acetylation, which influence activity and stability, further highlighting SRC-1′s importance in cellular signaling pathways. Anti-SRC-1 antibody (6D775) serves as an invaluable tool for researchers studying hormone signaling mechanisms and their implications in various diseases, including cancer.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SRC-1 Antibody (6D775) References:

1. Ligand-dependent degradation of SRC-1 is pivotal for progesterone receptor transcriptional activity.  |  Amazit, L., et al. 2011. Mol Endocrinol. 25: 394-408. PMID: 21273440
2. Small molecule inhibition of the steroid receptor coactivators, SRC-3 and SRC-1.  |  Wang, Y., et al. 2011. Mol Endocrinol. 25: 2041-53. PMID: 22053001
3. Knockout of SRC-1 and SRC-3 in Mice Decreases Cardiomyocyte Proliferation and Causes a Noncompaction Cardiomyopathy Phenotype.  |  Chen, X., et al. 2015. Int J Biol Sci. 11: 1056-72. PMID: 26221073
4. SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice.  |  Hinton, AO., et al. 2016. PLoS One. 11: e0168644. PMID: 28006821
5. The co-regulators SRC-1 and SMRT are involved in interleukin-6-induced androgen receptor activation.  |  Wang, Q., et al. 2016. Eur Cytokine Netw. 27: 108-113. PMID: 28396297
6. Targeted Degradation of Transcription Coactivator SRC-1 through the N-Degron Pathway.  |  Lee, Y., et al. 2020. Angew Chem Int Ed Engl. 59: 17548-17555. PMID: 33026161
7. Pharmacological inhibition of SRC-1 phase separation suppresses YAP oncogenic transcription activity.  |  Zhu, G., et al. 2021. Cell Res. 31: 1028-1031. PMID: 33850322
8. A missense mutation in the C. elegans src-2 tyrosine-protein kinase reduces brood size and enhances embryonic morphogenesis defects in src-1(RNAi) conditions.  |  Bai, X., et al. 2023. MicroPubl Biol. 2023: PMID: 37497183
9. Prostaglandins as Candidate Ligands for a Per-ARNT-Sim (PAS) Domain of Steroid Receptor Coactivator 1 (SRC1).  |  Daffern, N., et al. 2023. bioRxiv.. PMID: 37502902
10. Sarmentol H derived from Sedum sarmentosum Bunge directly targets FXR to mitigate cholestasis by recruiting SRC-1.  |  Liu, Z., et al. 2024. Phytomedicine. 130: 155759. PMID: 38788394

The preferred SRC-1 antibody is SRC-1 Antibody (1135/H4): sc-32789.