SRC-1 Antibody (1135/H4): sc-32789

SRC-1 Antibody (1135/H4) is a mouse monoclonal IgG1 kappa light chain antibody that detects SRC-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-SRC-1 antibody (1135/H4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SRC-1 protein, also known as steroid receptor coactivator-1, plays a crucial role in the regulation of gene expression by acting as a coactivator for nuclear hormone receptors, which are essential for mediating the effects of steroid hormones, thyroid hormones, and retinoic acids. SRC-1 is primarily located in the nucleus, where SRC-1 interacts with transcription factors to enhance the transcription of target genes. Nuclear localization of SRC-1 is vital because SRC-1 allows for precise regulation of gene expression in response to hormonal signals, thereby influencing various physiological processes such as metabolism, development, and reproduction. SRC-1 undergoes post-translational modifications, including phosphorylation, which can modulate activity and interactions with other proteins, further emphasizing SRC-1′s importance in cellular signaling pathways.

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SRC-1 Antibody (1135/H4) References:

1. SRC-1 Knockout Exerts No Effect on Amyloid β Deposition in APP/PS1 Mice.  |  Wu, Q., et al. 2020. Front Aging Neurosci. 12: 145. PMID: 32625077
2. Hydrophobic Tagging-Mediated Degradation of Transcription Coactivator SRC-1.  |  Choi, SR., et al. 2021. Int J Mol Sci. 22: PMID: 34203850
3. Src-1 and SP2 promote the proliferation and epithelial-mesenchymal transition of nasopharyngeal carcinoma.  |  Zhang, J., et al. 2021. Open Med (Wars). 16: 1061-1069. PMID: 34307888
4. Nuclear receptor coactivator SRC-1 promotes colorectal cancer progression through enhancing GLI2-mediated Hedgehog signaling.  |  Guo, P., et al. 2022. Oncogene. 41: 2846-2859. PMID: 35418691
5. Steroid Receptor Coactivator-1 (SRC-1) Promoted Cell Metastasis of Gastric Cancer via VEGFC Activator by NF-κB.  |  Zhao, X., et al. 2022. Crit Rev Eukaryot Gene Expr. 32: 21-29. PMID: 35695662
6. Targeting Nuclear Receptor Coactivator SRC-1 Prevents Colorectal Cancer Immune Escape by Reducing Transcription and Protein Stability of PD-L1.  |  Hong, Y., et al. 2024. Adv Sci (Weinh). 11: e2310037. PMID: 38953362
7. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily.  |  Oñate, SA., et al. 1995. Science. 270: 1354-7. PMID: 7481822
8. The nuclear hormone receptor gene superfamily.  |  Ribeiro, RC., et al. 1995. Annu Rev Med. 46: 443-53. PMID: 7598477
9. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors.  |  Hong, H., et al. 1996. Proc Natl Acad Sci U S A. 93: 4948-52. PMID: 8643509
10. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function.  |  Torchia, J., et al. 1997. Nature. 387: 677-84. PMID: 9192892
11. RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2.  |  Li, H., et al. 1997. Proc Natl Acad Sci U S A. 94: 8479-84. PMID: 9238002
12. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer.  |  Anzick, SL., et al. 1997. Science. 277: 965-8. PMID: 9252329

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SRC-1 Antibody (1135/H4) has 27 citations in a variety of scientific publications.

Primary antibodies like Anti-SRC-1 Antibody (1135/H4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SRC-1 Antibody (1135/H4) Specifications

Alternate Product Name: NCOA1

Product Clone Name: 1135/H4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 477-947

Epitope Target: SRC-1

Epitope Species:

Product Reactivity/Detection: SRC-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 27 citations in various scientific publications

Available Conjugates/Forms for SRC-1 Antibody (1135/H4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent