SR-A Antibody (C-6): sc-166140

SR-A Antibody (C-6) is a mouse monoclonal IgG2b antibody that detects scavenger receptor class A (SR-A) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SR-A is a critical protein involved in the uptake of modified low-density lipoprotein (LDL), which plays a significant role in lipid metabolism and atherosclerosis. The gene encoding human SR-A is located on chromosome 8 and produces two main isoforms, SR-AI and SR-AII, both of which are essential for mediating LDL uptake in atherosclerotic lesions. SR-AI and SR-AII contain six distinct domains that contribute to their function, with domain IV being crucial for trimerization and domain V facilitating a broad range of ligand recognition. SR-A is expressed in key tissues such as the liver, placenta, and brain, highlighting SR-A′s importance in various physiological and pathological processes, including host defense and cell adhesion. A third isoform, SR-AIII, does not participate in LDL uptake and may serve as a dominant negative isoform, potentially offering protective effects in advanced atherosclerotic lesions. Anti-SR-A antibody (C-6) serves as an invaluable tool for researchers studying SR-A′s implications in diseases like atherosclerosis and Alzheimer′s disease, as well as SR-A′s broader role in macrophage-associated processes.

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SR-A Antibody (C-6) References:

1. Reduced infiltration of class A scavenger receptor positive antigen-presenting cells is associated with prostate cancer progression.  |  Yang, G., et al. 2004. Cancer Res. 64: 2076-82. PMID: 15026346
2. The effect of class a scavenger receptor deficiency in bone.  |  Lin, YL., et al. 2007. J Biol Chem. 282: 4653-4660. PMID: 17166840
3. Class A scavenger receptor (CD204) attenuates hyperoxia-induced lung injury by reducing oxidative stress.  |  Kobayashi, H., et al. 2007. J Pathol. 212: 38-46. PMID: 17370294
4. 4-hydroxynonenal contributes to macrophage foam cell formation through increased expression of class A scavenger receptor at the level of translation.  |  Yun, MR., et al. 2008. Free Radic Biol Med. 45: 177-83. PMID: 18456003
5. C-reactive protein uptake by macrophage cell line via class-A scavenger receptor.  |  Fujita, Y., et al. 2010. Clin Chem. 56: 478-81. PMID: 20075180
6. The class A scavenger receptor, macrophage receptor with collagenous structure, is the major phagocytic receptor for Clostridium sordellii expressed by human decidual macrophages.  |  Thelen, T., et al. 2010. J Immunol. 185: 4328-35. PMID: 20810988
7. Suppression of TLR4-mediated inflammatory response by macrophage class A scavenger receptor (CD204).  |  Ohnishi, K., et al. 2011. Biochem Biophys Res Commun. 411: 516-22. PMID: 21756882
8. Major vault protein regulates class A scavenger receptor-mediated tumor necrosis factor-α synthesis and apoptosis in macrophages.  |  Ben, J., et al. 2013. J Biol Chem. 288: 20076-84. PMID: 23703615
9. A cross talk between class A scavenger receptor and receptor for advanced glycation end-products contributes to diabetic retinopathy.  |  Ma, K., et al. 2014. Am J Physiol Endocrinol Metab. 307: E1153-65. PMID: 25352436
10. Class A Scavenger Receptor Exacerbates Osteoclastogenesis by an Interleukin-6-Mediated Mechanism through ERK and JNK Signaling Pathways.  |  Guo, S., et al. 2016. Int J Biol Sci. 12: 1155-1167. PMID: 27766031

The preferred SR-A antibody is SR-A Antibody (E-5): sc-166184.