SR-2B Antibody (H-11): sc-376834

SR-2B Antibody (H-11) is a mouse monoclonal IgG2b antibody that detects SR-2B in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SR-2B, a subtype of the serotonin receptor family, plays a crucial role in mediating serotonin effects, particularly in the cardiovascular system and brain. SR-2B is primarily located in the heart, brain, and gastrointestinal tract, where SR-2B influences vital physiological processes such as cardiac function, mood regulation, and gastrointestinal motility. SR-2B presence in these tissues underscores SR-2B importance in both normal physiology and disease pathology, including cardiac disorders and psychiatric conditions. SR-2B interacts with several key proteins, including G proteins and phospholipase C, which are essential for signal transduction pathways regulating intracellular calcium levels and other downstream effects. SR-2B′s ability to modulate these pathways highlights SR-2B potential as a therapeutic target for conditions such as depression, anxiety, and cardiovascular diseases, making anti-SR-2B antibody (H-11) an invaluable tool for researchers studying these critical areas.

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SR-2B Antibody (H-11) References:

1. The potential role of myocardial serotonin receptor 2B expression in canine dilated cardiomyopathy.  |  Fonfara, S., et al. 2014. Vet J. 199: 406-12. PMID: 24440442
2. Serotonin Receptor 2B Mediates Mechanical Hyperalgesia by Regulating Transient Receptor Potential Vanilloid 1.  |  Su, YS., et al. 2016. J Mol Neurosci. 59: 113-25. PMID: 26635025
3. Up-regulation of serotonin receptor 2B mRNA and protein in the peri-infarcted area of aged rats and stroke patients.  |  Buga, AM., et al. 2016. Oncotarget. 7: 17415-30. PMID: 27013593
4. Serotonin receptor 2B signaling with interstitial cell activation and leaflet remodeling in degenerative mitral regurgitation.  |  Driesbaugh, KH., et al. 2018. J Mol Cell Cardiol. 115: 94-103. PMID: 29291394
5. Expression of the serotonin receptor 2B in uveal melanoma and effects of an antagonist on cell lines.  |  Weidmann, C., et al. 2018. Clin Exp Metastasis. 35: 123-134. PMID: 29696577
6. Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice.  |  Lee, SH., et al. 2018. J Allergy Clin Immunol. 142: 1349-1352.e16. PMID: 29920354
7. Targeting serotonin receptor 2B inhibits TGFβ induced differentiation of human vascular smooth muscle cells.  |  Wenglén, C., et al. 2023. Eur J Pharmacol. 944: 175570. PMID: 36781042
8. Identification of Potent, Selective, and Peripherally Restricted Serotonin Receptor 2B Antagonists from a High-Throughput Screen.  |  Bender, AM., et al. 2023. Assay Drug Dev Technol. 21: 89-96. PMID: 36930852
9. Variant rs17619600 in the gene encoding serotonin receptor 2B (HTR2B) increases the risk of gestational diabetes mellitus: a case-control study.  |  Penno, JRCZ., et al. 2023. Eur J Med Res. 28: 243. PMID: 37480094
10. Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome.  |  Li, ZY., et al. 2024. World J Gastroenterol. 30: 1431-1449. PMID: 38596485

The preferred SR-2B antibody is SR-2B Antibody (C-6): sc-376878.