SR-2B Antibody (C-6): sc-376878

SR-2B Antibody (C-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects SR-2B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SR-2B (C-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SR-2B protein, also known as 5-Hydroxytryptamine Receptor 2B, is a member of the G protein-coupled receptor family and plays a crucial role in mediating serotonin effects, a key neurotransmitter involved in numerous physiological processes. SR-2B is primarily located in the cardiovascular system, gastrointestinal tract, and central nervous system, where SR-2B influences critical functions such as cardiac contractility, gastrointestinal motility, and various neurobehavioral processes. SR-2B′s ability to activate phospholipase C and release intracellular calcium stores is vital for function, particularly in cardiac disorders, where SR-2B contributes to the pathology of conditions such as heart failure and arrhythmias. Additionally, SR-2B′s interaction with other proteins, including various signaling molecules, underscores SR-2B′s importance in both normal physiology and disease states, making anti-SR-2B antibody (C-6) an essential tool for researchers studying serotonin signaling pathways and their implications in health and disease.

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SR-2B Antibody (C-6) References:

1. Cellular localization of serotonin(2A) (5HT(2A)) receptors in the rat brain.  |  Xu, T. and Pandey, SC. 2000. Brain Res Bull. 51: 499-505. PMID: 10758340
2. Serotonin 2B receptor is required for heart development.  |  Nebigil, CG., et al. 2000. Proc Natl Acad Sci U S A. 97: 9508-13. PMID: 10944220
3. Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors.  |  Herrick-Davis, K., et al. 2000. J Pharmacol Exp Ther. 295: 226-32. PMID: 10991983
4. Role of 5-HT in the regulation of the brain-pituitary-adrenal axis: effects of 5-HT on adrenocortical cells.  |  Contesse, V., et al. 2000. Can J Physiol Pharmacol. 78: 967-83. PMID: 11149386
5. Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice.  |  Gingrich, JA. and Hen, R. 2001. Psychopharmacology (Berl). 155: 1-10. PMID: 11374326
6. The human serotonin receptor 2B: coding region polymorphisms and association with vulnerability to illegal drug abuse.  |  Lin, Z., et al. 2004. Pharmacogenetics. 14: 805-11. PMID: 15608559
7. Activation of serotonin receptor-2B rescues small-for-size liver graft failure in mice.  |  Tian, Y., et al. 2011. Hepatology. 53: 253-62. PMID: 21254175
8. Analysis of the proteasome activity and the turnover of the serotonin receptor 2B (HTR2B) in human uveal melanoma.  |  Le-Bel, G., et al. 2019. Exp Eye Res. 184: 72-77. PMID: 31002821
9. Genetic ablation of serotonin receptor 2B improves aortic valve hemodynamics of Notch1 heterozygous mice in a high-cholesterol diet model.  |  Joll, JE., et al. 2020. PLoS One. 15: e0238407. PMID: 33237915
10. Glucocorticoid Inhibition of Estrogen Regulation of the Serotonin Receptor 2B in Cardiomyocytes Exacerbates Cell Death in Hypoxia/Reoxygenation Injury.  |  Dhaibar, HA., et al. 2021. J Am Heart Assoc. 10: e015868. PMID: 34472367
11. Contractile serotonin-2A receptor signal transduction in guinea pig trachea: importance of protein kinase C and extracellular and intracellular calcium but not phosphoinositide hydrolysis.  |  Watts, SW., et al. 1994. J Pharmacol Exp Ther. 271: 832-44. PMID: 7965803
12. Signaling pathways mediating induction of the early response genes prostaglandin G/H synthase-2 and egr-1 by serotonin via 5-HT2A receptors.  |  Goppelt-Struebe, M. and Stroebel, M. 1998. J Cell Physiol. 175: 341-7. PMID: 9572479

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SR-2B Antibody (C-6) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-SR-2B Antibody (C-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SR-2B Antibody (C-6) Specifications

Alternate Product Name: HTR2B

Product Clone Name: C-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 387-481

Epitope Target: SR-2B

Epitope Species: human

Product Reactivity/Detection: serotonin 2B receptor (5-HT2B)

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for SR-2B Antibody (C-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin