Squalene synthetase Antibody (A-7): sc-271602
- Squalene synthetase Antibody (A-7) is a mouse monoclonal IgG1 κ Squalene synthetase antibody, cited in 10 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of Squalene synthetase of human origin
- Squalene synthetase Antibody (A-7) is recommended for detection of Squalene synthetase of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Squalene synthetase Antibody (A-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Squalene synthetase Antibody (A-7) for WB and IHC(P) applications. These reagents are now offered in bundles with Squalene synthetase Antibody (A-7) (see ordering information below).
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Squalene synthetase Antibody (A-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects Squalene synthetase protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Squalene synthetase antibody (A-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Squalene synthetase plays a crucial role in cholesterol biosynthesis, catalyzing the conversion of transfarnesyl-diphosphate to squalene, which is the first specific step in the mevalonate pathway. Squalene synthetase is located in the endoplasmic reticulum and is essential for the production of isoprenoids, which are vital for various cellular functions, including membrane integrity and signaling. Squalene synthetase functions extend beyond cholesterol synthesis, as Squalene synthetase is also involved in the biosynthesis of other sterols and isoprenoids that are critical for cellular health and function. Squalene synthetase may interact with squalene epoxidase, a key enzyme in sterol biosynthesis, suggesting a collaborative role in regulating the pathway′s efficiency and output.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Squalene synthetase Antibody (A-7) References:
- Overexpression of squalene synthase in Eleutherococcus senticosus increases phytosterol and triterpene accumulation. | Seo, JW., et al. 2005. Phytochemistry. 66: 869-77. PMID: 15845405
- Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa. | Orenes Lorente, S., et al. 2005. Bioorg Med Chem. 13: 3519-29. PMID: 15848765
- New lipid-lowering agents acting on LDL receptors. | Scharnagl, H. and März, W. 2005. Curr Top Med Chem. 5: 233-42. PMID: 15857307
- Studies of the FABP family: a retrospective. | Ono, T. 2005. Mol Cell Biochem. 277: 1-6. PMID: 16132708
- Antiproliferative and ultrastructural effects of BPQ-OH, a specific inhibitor of squalene synthase, on Leishmania amazonensis. | Rodrigues, JC., et al. 2005. Exp Parasitol. 111: 230-8. PMID: 16198340
- Dual roles for cholesterol in mammalian cells. | Xu, F., et al. 2005. Proc Natl Acad Sci U S A. 102: 14551-6. PMID: 16199524
- Preparation, characterization, and optimization of an in vitro C30 carotenoid pathway. | Ku, B., et al. 2005. Appl Environ Microbiol. 71: 6578-83. PMID: 16269684
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Squalene synthetase Antibody (A-7) | sc-271602 | 200 µg/ml | $316.00 | |||
Squalene synthetase Antibody (A-7): m-IgG Fc BP-HRP Bundle | sc-527262 | 200 µg Ab; 10 µg BP | $354.00 | |||
Squalene synthetase Antibody (A-7): m-IgG1 BP-HRP Bundle | sc-532635 | 200 µg Ab; 20 µg BP | $354.00 | |||
Squalene synthetase Antibody (A-7) AC | sc-271602 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Squalene synthetase Antibody (A-7) HRP | sc-271602 HRP | 200 µg/ml | $316.00 | |||
Squalene synthetase Antibody (A-7) FITC | sc-271602 FITC | 200 µg/ml | $330.00 | |||
Squalene synthetase Antibody (A-7) PE | sc-271602 PE | 200 µg/ml | $343.00 | |||
Squalene synthetase Antibody (A-7) Alexa Fluor® 488 | sc-271602 AF488 | 200 µg/ml | $357.00 | |||
Squalene synthetase Antibody (A-7) Alexa Fluor® 546 | sc-271602 AF546 | 200 µg/ml | $357.00 | |||
Squalene synthetase Antibody (A-7) Alexa Fluor® 594 | sc-271602 AF594 | 200 µg/ml | $357.00 | |||
Squalene synthetase Antibody (A-7) Alexa Fluor® 647 | sc-271602 AF647 | 200 µg/ml | $357.00 | |||
Squalene synthetase Antibody (A-7) Alexa Fluor® 680 | sc-271602 AF680 | 200 µg/ml | $357.00 | |||
Squalene synthetase Antibody (A-7) Alexa Fluor® 790 | sc-271602 AF790 | 200 µg/ml | $357.00 |