SQSTM1/p62 Antibody (A-6): sc-48402
- SQSTM1/p62 Antibody (A-6) is a mouse monoclonal IgG1 κ, cited in 89 publications, provided at 200 µg/ml
- raised against amino acids 151-440 of SQSTM1 of human origin
- Anti-SQSTM1/p62 Antibody (A-6) is recommended for detection of SQSTM1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-SQSTM1/p62 Antibody (A-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for SQSTM1/p62 Antibody (A-6) for WB and IHC(P) applications. These reagents are now offered in bundles with SQSTM1/p62 Antibody (A-6) (see ordering information below).
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SQSTM1 Antibody (A-6) is a mouse monoclonal IgG1 kappa kappa light chain antibody engineered to specifically detect SQSTM1, also known as p60, p62, A170, DMRV, OSIL, PDB3, ZIP3, p62B, EBIAP, NADGP, and FTDALS3, across multiple species including mouse, rat, and human. Anti-SQSTM1 antibody (A-6) targets the amino acid region 151-440 of the human SQSTM1 protein in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SQSTM1 is a multifunctional adaptor protein involved in various cellular processes, including autophagy, where SQSTM1 facilitates the selective degradation of ubiquitinated proteins by interacting with LC3 on autophagosomes. Additionally, SQSTM1 interacts with key signaling proteins such as TRAF6, which plays a pivotal role in the NF-κB signaling pathway, and Keap1, which regulates the Nrf2 pathway involved in oxidative stress responses. These interactions are crucial for maintaining cellular homeostasis and regulating inflammation, apoptosis, and oxidative stress responses. SQSTM1′s binding to ubiquitinated proteins is further modulated by post-translational modifications, including phosphorylation and ubiquitination, which enhance binding affinity and functional versatility in signaling pathways and autophagic flux. SQSTM1 (A-6) antibody is available in both non-conjugated form and conjugated forms such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing researchers with versatile options for diverse experimental needs. Anti-SQSTM1 antibody (A-6) is instrumental in studying pathological conditions like Paget′s disease of bone, where mutations in the ubiquitin-associated (UBA) domain of SQSTM1 disrupt normal function in aggregate sequestration and cell survival, leading to abnormal bone remodeling and increased bone fragility. SQSTM1 monoclonal antibody (A-6) enables researchers to gain comprehensive insights into molecular interactions and regulatory mechanisms of SQSTM1, facilitating advancements in understanding disease mechanisms and developing targeted therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SQSTM1/p62 Antibody (A-6) | sc-48402 | 200 µg/ml | $322.00 | |||
SQSTM1/p62 Antibody (A-6): m-IgG Fc BP-HRP Bundle | sc-526748 | 200 µg Ab; 10 µg BP | $361.00 | |||
SQSTM1/p62 Antibody (A-6): m-IgG1 BP-HRP Bundle | sc-532121 | 200 µg Ab; 20 µg BP | $361.00 | |||
SQSTM1/p62 Antibody (A-6) AC | sc-48402 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SQSTM1/p62 Antibody (A-6) HRP | sc-48402 HRP | 200 µg/ml | $322.00 | |||
SQSTM1/p62 Antibody (A-6) FITC | sc-48402 FITC | 200 µg/ml | $336.00 | |||
SQSTM1/p62 Antibody (A-6) PE | sc-48402 PE | 200 µg/ml | $349.00 | |||
SQSTM1/p62 Antibody (A-6) Alexa Fluor® 488 | sc-48402 AF488 | 200 µg/ml | $364.00 | |||
SQSTM1/p62 Antibody (A-6) Alexa Fluor® 546 | sc-48402 AF546 | 200 µg/ml | $364.00 | |||
SQSTM1/p62 Antibody (A-6) Alexa Fluor® 594 | sc-48402 AF594 | 200 µg/ml | $364.00 | |||
SQSTM1/p62 Antibody (A-6) Alexa Fluor® 647 | sc-48402 AF647 | 200 µg/ml | $364.00 | |||
SQSTM1/p62 Antibody (A-6) Alexa Fluor® 680 | sc-48402 AF680 | 200 µg/ml | $364.00 | |||
SQSTM1/p62 Antibody (A-6) Alexa Fluor® 790 | sc-48402 AF790 | 200 µg/ml | $364.00 |