Sprouty 3 Antibody (C-2): sc-374593

Sprouty 3 Antibody (C-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects Sprouty 3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Sprouty 3 antibody (C-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Sprouty 3 plays a crucial role as a negative regulator of growth factor signaling, particularly in fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) pathways, which are essential for processes such as cell proliferation and angiogenesis. Sprouty 3 is primarily expressed in adult brain and testis, distinguishing this protein from other Sprouty family members that are more widely distributed. Expression in these specific tissues suggests a specialized function in neuronal and reproductive signaling pathways. Sprouty 3 interacts with various signaling molecules, which may modulate activity and influence cellular responses to growth factors. Through inhibition of FGF and VEGF-mediated cell proliferation, Sprouty 3 may play a significant role in regulating angiogenesis in both normal physiological processes and pathological conditions, making this protein a valuable target for research in developmental biology and cancer studies.

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Sprouty 3 Antibody (C-2) References:

1. Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain.  |  Lim, J., et al. 2000. J Biol Chem. 275: 32837-45. PMID: 10887178
2. Inhibition of angiogenesis by a mouse sprouty protein.  |  Lee, SH., et al. 2001. J Biol Chem. 276: 4128-33. PMID: 11053436
3. Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells.  |  Impagnatiello, MA., et al. 2001. J Cell Biol. 152: 1087-98. PMID: 11238463
4. The C terminus of sprouty is important for modulation of cellular migration and proliferation.  |  Yigzaw, Y., et al. 2001. J Biol Chem. 276: 22742-7. PMID: 11279012
5. Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis.  |  Mailleux, AA., et al. 2001. Mech Dev. 102: 81-94. PMID: 11287183
6. ERK pathway positively regulates the expression of Sprouty genes.  |  Ozaki, K., et al. 2001. Biochem Biophys Res Commun. 285: 1084-8. PMID: 11478764
7. Maintenance of X- and Y-inactivation of the pseudoautosomal (PAR2) gene SPRY3 is independent from DNA methylation and associated to multiple layers of epigenetic modifications.  |  De Bonis, ML., et al. 2006. Hum Mol Genet. 15: 1123-32. PMID: 16500999
8. The VASP-Spred-Sprouty domain puzzle.  |  Bundschu, K., et al. 2006. J Biol Chem. 281: 36477-81. PMID: 16987806
9. Sprouty proteins: modified modulators, matchmakers or missing links?  |  Guy, GR., et al. 2009. J Endocrinol. 203: 191-202. PMID: 19423641
10. Epigenetic regulation in human melanoma: past and future.  |  Sarkar, D., et al. 2015. Epigenetics. 10: 103-21. PMID: 25587943
11. Sprouty-Related Ena/Vasodilator-Stimulated Phosphoprotein Homology 1-Domain-Containing Protein-2 Critically Regulates Influenza A Virus-Induced Pneumonia.  |  Ito, T., et al. 2016. Crit Care Med. 44: e530-43. PMID: 26757161
12. Signal Transduction Regulators in Axonal Regeneration.  |  Hausott, B., et al. 2022. Cells. 11: PMID: 35563843

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Sprouty 3 Antibody (C-2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Sprouty 3 Antibody (C-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Sprouty 3 Antibody (C-2) Specifications

Alternate Product Name: Sprouty 3

Product Clone Name: C-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-95

Epitope Target: Sprouty 3

Epitope Species: human

Product Reactivity/Detection: Sprouty 3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Sprouty 3 Antibody (C-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin