SPR Antibody (H-12): sc-398126
- SPR Antibody (H-12) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 191-214 near the C-terminus of SPR of human origin
- recommended for detection of SPR of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and canine
- m-IgGκ BP-HRP is the preferred secondary detection reagent for SPR Antibody (H-12) for WB applications. This reagent is now offered in a bundle with SPR Antibody (H-12) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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SPR Antibody (H-12) is a mouse monoclonal IgG2b antibody that detects sepiapterin reductase (SPR) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SPR antibody (H-12) recognizes SPR, a homodimeric cytoplasmic protein that plays a crucial role in the biosynthesis of tetrahydrobiopterin (BH4), an essential cofactor for the hydroxylation of aromatic amino acids, including tryptophan, tyrosine, and phenylalanine. SPR (H-12) antibody is vital for studying BH4′s role in dopamine synthesis, as disruptions in this pathway can lead to severe neurological disorders. Notably, mutations in the SPR gene can result in sepiapterin reductase deficiency, which is characterized by monoamine neurotransmitter deficiencies without hyperphenylalaninemia, leading to conditions such as DOPA-responsive dystonia. Increased expression of SPR mRNA has been observed in the brains of Parkinson′s Disease patients, indicating a potential involvement of SPR in the pathophysiology of this neurodegenerative disorder. SPR (H-12) monoclonal antibody serves as an invaluable tool for researchers studying SPR′s role in various biological processes and diseases, providing insights into its function and potential therapeutic targets.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SPR Antibody (H-12) | sc-398126 | 200 µg/ml | $322.00 | |||
SPR Antibody (H-12): m-IgGκ BP-HRP Bundle | sc-535976 | 200 µg Ab; 40 µg BP | $361.00 | |||
SPR (H-12) Neutralizing Peptide | sc-398126 P | 100 µg/0.5 ml | $69.00 |