spectrin β I Antibody (B-1): sc-374309

spectrin β I Antibody (B-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects spectrin beta I protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-spectrin beta I antibody (B-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Spectrin beta I maintains structural integrity and functionality of plasma membrane, particularly in erythrocytes, where spectrin beta I forms part of the cytoskeletal framework. Spectrin beta I interacts with actin filaments to create a resilient network supporting cell shape and flexibility. Spectrin beta I enables erythrocyte deformability, allowing red blood cells to navigate through narrow capillaries without rupturing. Spectrin beta I participates in cellular signaling and membrane trafficking, highlighting broader functions beyond structural support. Spectrin dimers and tetramers in erythrocytes regulate membrane dynamics, with tetramers acting as barriers to lateral diffusion, contributing to membrane stability. Research on spectrin beta I function and interactions helps understand its role in health and disease, particularly in conditions affecting red blood cell morphology and function.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

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spectrin β I Antibody (B-1) References:

1. Spectrin redistributes to the cytosol and is phosphorylated during mitosis in cultured cells.  |  Fowler, VM. and Adam, EJ. 1992. J Cell Biol. 119: 1559-72. PMID: 1469048
2. α-Synuclein modulates neurite outgrowth by interacting with SPTBN1.  |  Lee, HJ., et al. 2012. Biochem Biophys Res Commun. 424: 497-502. PMID: 22771809
3. Functional diversity among spectrin isoforms.  |  Coleman, TR., et al. 1989. Cell Motil Cytoskeleton. 12: 225-47. PMID: 2655937
4. The spectrin network as a barrier to lateral diffusion in erythrocytes. A percolation analysis.  |  Saxton, MJ. 1989. Biophys J. 55: 21-8. PMID: 2930822
5. Co-expression analysis of pancreatic cancer proteome reveals biology and prognostic biomarkers.  |  Mantini, G., et al. 2020. Cell Oncol (Dordr). 43: 1147-1159. PMID: 32860207
6. SPTBN1 Prevents Primary Osteoporosis by Modulating Osteoblasts Proliferation and Differentiation and Blood Vessels Formation in Bone.  |  Xu, X., et al. 2021. Front Cell Dev Biol. 9: 653724. PMID: 33816505
7. Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and Development.  |  Chen, S., et al. 2022. Cell Mol Gastroenterol Hepatol. 13: 949-973.e7. PMID: 34737104
8. Prognostic implications of N6-methyladenosine RNA regulators in breast cancer.  |  Tai, J., et al. 2022. Sci Rep. 12: 1222. PMID: 35075167
9. The present status of erythrocyte spectrin structure: the 106-residue repetitive structure is a basic feature of an entire class of proteins.  |  Speicher, DW. 1986. J Cell Biochem. 30: 245-58. PMID: 3517024
10. Modulation of spectrin-actin assembly by erythrocyte adducin.  |  Gardner, K. and Bennett, V. Nature. 328: 359-62. PMID: 3600811
11. Brain alpha erythroid spectrin: identification, compartmentalization, and beta spectrin associations.  |  Clark, MB., et al. 1994. Brain Res. 663: 223-36. PMID: 7874505
12. A partial structural repeat forms the heterodimer self-association site of all beta-spectrins.  |  Kennedy, SP., et al. 1994. J Biol Chem. 269: 11400-8. PMID: 8157672

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-spectrin β I Antibody (B-1) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-spectrin β I Antibody (B-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

spectrin β I Antibody (B-1) Specifications

Alternate Product Name: spectrin β I

Product Clone Name: B-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2111-2137

Epitope Target: spectrin β I

Epitope Species: human

Product Reactivity/Detection: spectrin β I

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for spectrin β I Antibody (B-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin