spectrin β I Antibody (4C3): sc-58851
- spectrin β I Antibody (4C3) is a mouse monoclonal IgG1 provided at 200 µg/ml
- raised against purified erythrocyte spectrin β I of human origin
- recommended for detection of spectrin β I of mouse, rat and human origin by WB, IP and IF; non cross-reactive with spectrin α or either of the fodrin subunits
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for spectrin β I Antibody (4C3). This work is in progress.
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SEE ALSO...
Spectrin β I Antibody (4C3) is a mouse monoclonal IgG1 antibody that detects spectrin β I in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Spectrin β I plays a crucial role in maintaining the structural integrity and stability of the cytoskeleton, particularly in erythrocytes, where spectrin β I forms part of the spectrin cytoskeletal network that underpins the plasma membrane. Spectrin β I is essential for preserving the unique biconcave shape of red blood cells, which is vital for their flexibility and ability to navigate through the microvasculature. The spectrin β I subunit pairs with spectrin α I to form heterodimers, which then assemble into larger oligomeric structures that provide mechanical support and organization to the membrane. Disruption of spectrin β I function can lead to various hematological disorders, highlighting spectrin β I′s importance in cellular architecture and function. Anti-spectrin β I antibody (4C3) is an invaluable tool for researchers studying cytoskeletal dynamics, membrane integrity, and related pathologies.
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spectrin β I Antibody (4C3) References:
- SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma. | Lin, L., et al. 2021. Theranostics. 11: 4232-4250. PMID: 33754058
- Heterozygous variants in SPTBN1 cause intellectual disability and autism. | Rosenfeld, JA., et al. 2021. Am J Med Genet A. 185: 2037-2045. PMID: 33847457
- Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome. | Cousin, MA., et al. 2021. Nat Genet. 53: 1006-1021. PMID: 34211179
- SPTBN1 abrogates renal clear cell carcinoma progression via glycolysis reprogramming in a GPT2-dependent manner. | Wu, J., et al. 2022. J Transl Med. 20: 603. PMID: 36527113
- Revealing the Organ-Specific Expression of SPTBN1 using Single-Cell RNA Sequencing Analysis. | Jung, J. and Wu, Q. 2023. bioRxiv.. PMID: 37333135
- Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity. | Birker, K., et al. 2023. Elife. 12: PMID: 37404133
- METTL3-mediated m6 A modification of circPRKAR1B promotes Crohn's colitis by inducing pyroptosis via autophagy inhibition. | Zhao, J., et al. 2023. Clin Transl Med. 13: e1405. PMID: 37679886
- Analysis of immunoinfiltration and EndoMT based on TGF-β signaling pathway-related genes in acute myocardial infarction. | Shen, J., et al. 2024. Sci Rep. 14: 5183. PMID: 38431730
- Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation. | He, J., et al. 2024. Brain. 147: 3395-3408. PMID: 38454550
- Aldehydes alter TGF-β signaling and induce obesity and cancer. | Yang, X., et al. 2024. Cell Rep. 43: 114676. PMID: 39217614
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
spectrin β I Antibody (4C3) | sc-58851 | 200 µg/ml | $322.00 |