Spartin Antibody (D-4): sc-271888
- Spartin Antibody (D-4) is a mouse monoclonal IgG1 κ Spartin antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-141 mapping at the N-terminus of Spartin of human origin
- Spartin Antibody (D-4) is recommended for detection of Spartin of human origin by WB, IP, IF and ELISA
- Anti-Spartin Antibody (D-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Spartin Antibody (D-4) for WB applications. These reagents are now offered in bundles with Spartin Antibody (D-4) (see ordering information below).
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SEE ALSO...
Spartin Antibody (D-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Spartin protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Spartin (D-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Spartin protein plays a crucial role in microtubule dynamics and endosomal trafficking, which are essential processes for maintaining cellular structure and function. Specifically, Spartin contains a microtubule interacting and trafficking (MIT) domain that facilitates interaction with microtubules, thereby influencing intracellular transport and organization. Spartin is ubiquitously expressed, with highest levels found in adipose tissue, highlighting importance in metabolic processes. Notably, a frameshift mutation in SPG20 is linked to spastic paraplegia 20, also known as Troyer syndrome, an autosomal recessive disorder characterized by progressive weakness and stiffness in lower extremities due to retrograde axonopathy of corticospinal motor neurons. Spartin′s interaction with other proteins involved in these pathways underscores significance in both normal cellular function and disease mechanisms, making anti-Spartin antibody (D-4) a valuable tool for researchers studying these critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Spartin Antibody (D-4) References:
- SPG20 is mutated in Troyer syndrome, an hereditary spastic paraplegia. | Patel, H., et al. 2002. Nat Genet. 31: 347-8. PMID: 12134148
- Familial spastic paraplegia with distal muscle wasting in the Old Order Amish; atypical Troyer syndrome or 'new' syndrome. | Neuhäuser, G., et al. 1976. Clin Genet. 9: 315-23. PMID: 1261070
- The identification of a conserved domain in both spartin and spastin, mutated in hereditary spastic paraplegia. | Ciccarelli, FD., et al. 2003. Genomics. 81: 437-41. PMID: 12676568
- Troyer syndrome revisited. A clinical and radiological study of a complicated hereditary spastic paraplegia. | Proukakis, C., et al. 2004. J Neurol. 251: 1105-10. PMID: 15372254
- The Troyer syndrome (SPG20) protein spartin interacts with Eps15. | Bakowska, JC., et al. 2005. Biochem Biophys Res Commun. 334: 1042-8. PMID: 16036216
- Thin corpus callosum and amyotrophy in spastic paraplegia--case report and review of literature. | Winner, B., et al. 2006. Clin Neurol Neurosurg. 108: 692-8. PMID: 16102895
- Troyer syndrome protein spartin is mono-ubiquitinated and functions in EGF receptor trafficking. | Bakowska, JC., et al. 2007. Mol Biol Cell. 18: 1683-92. PMID: 17332501
- The Troyer syndrome. A recessive form of spastic paraplegia with distal muscle wasting. | Cross, HE. and McKusick, VA. 1967. Arch Neurol. 16: 473-85. PMID: 6022528
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Spartin Antibody (D-4) | sc-271888 | 200 µg/ml | $322.00 | |||
Spartin Antibody (D-4): m-IgG Fc BP-HRP Bundle | sc-529278 | 200 µg Ab; 10 µg BP | $361.00 | |||
Spartin Antibody (D-4): m-IgGκ BP-HRP Bundle | sc-522089 | 200 µg Ab, 40 µg BP | $361.00 | |||
Spartin Antibody (D-4): m-IgG1 BP-HRP Bundle | sc-543430 | 200 µg Ab; 20 µg BP | $361.00 | |||
Spartin Antibody (D-4) AC | sc-271888 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Spartin Antibody (D-4) HRP | sc-271888 HRP | 200 µg/ml | $322.00 | |||
Spartin Antibody (D-4) FITC | sc-271888 FITC | 200 µg/ml | $336.00 | |||
Spartin Antibody (D-4) PE | sc-271888 PE | 200 µg/ml | $349.00 | |||
Spartin Antibody (D-4) Alexa Fluor® 488 | sc-271888 AF488 | 200 µg/ml | $364.00 | |||
Spartin Antibody (D-4) Alexa Fluor® 546 | sc-271888 AF546 | 200 µg/ml | $364.00 | |||
Spartin Antibody (D-4) Alexa Fluor® 594 | sc-271888 AF594 | 200 µg/ml | $364.00 | |||
Spartin Antibody (D-4) Alexa Fluor® 647 | sc-271888 AF647 | 200 µg/ml | $364.00 | |||
Spartin Antibody (D-4) Alexa Fluor® 680 | sc-271888 AF680 | 200 µg/ml | $364.00 | |||
Spartin Antibody (D-4) Alexa Fluor® 790 | sc-271888 AF790 | 200 µg/ml | $364.00 |