SPACR Antibody (G-11): sc-377366

SPACR Antibody (G-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects SPACR protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SPACR Antibody (G-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SPACR protein, also known as interphotoreceptor matrix proteoglycan 1 (IMPG1) or IPM150, is a 797 amino acid secreted protein characterized by the presence of two SEA domains. SPACR protein plays a crucial role in forming the interphotoreceptor matrix, a specialized extracellular matrix in the retina that supports the structural integrity and function of photoreceptor cells. SPACR protein is predominantly expressed in the retina, specifically by cone and rod photoreceptor cells, where SPACR is essential for maintaining the organization and communication between these cells and the retinal pigment epithelium. The gene encoding SPACR spans approximately 151,564 bases and is located on human chromosome 6q14, a region associated with various genetic disorders, including porphyria cutanea tarda and Parkinson′s disease. SPACR protein′s ability to interact with hyaluronan suggests involvement in forming a macromolecular scaffold that is vital for retinal health and function, making SPACR an important target for research in vision-related studies.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SPACR Antibody (G-11) References:

1. Expression and characterization of the IPM 150 gene (IMPG1) product, a novel human photoreceptor cell-associated chondroitin-sulfate proteoglycan.  |  Kuehn, MH. and Hageman, GS. 1999. Matrix Biol. 18: 509-18. PMID: 10601738
2. Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27.  |  Cesari, R., et al. 2003. Proc Natl Acad Sci U S A. 100: 5956-61. PMID: 12719539
3. Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus.  |  Fan, J., et al. 2010. Am J Med Genet B Neuropsychiatr Genet. 153B: 29-37. PMID: 19308960
4. Associations among behavior-related susceptibility factors in porphyria cutanea tarda.  |  Jalil, S., et al. 2010. Clin Gastroenterol Hepatol. 8: 297-302, 302.e1. PMID: 19948245
5. Genomic organization and chromosomal localization of the interphotoreceptor matrix proteoglycan-1 (IMPG1) gene: a candidate for 6q-linked retinopathies.  |  Felbor, U., et al. 1998. Cytogenet Cell Genet. 81: 12-7. PMID: 9691169
6. Assessment of the interphotoreceptor matrix proteoglycan-1 (IMPG1) gene localised to 6q13-q15 in autosomal dominant Stargardt-like disease (ADSTGD), progressive bifocal chorioretinal atrophy (PBCRA), and North Carolina macular dystrophy (MCDR1).  |  Gehrig, A., et al. 1998. J Med Genet. 35: 641-5. PMID: 9719369
7. Characterization of SPACR, a sialoprotein associated with cones and rods present in the interphotoreceptor matrix of the human retina: immunological and lectin binding analysis.  |  Acharya, S., et al. 1998. Glycobiology. 8: 997-1006. PMID: 9719680
8. SPACR, a novel interphotoreceptor matrix glycoprotein in human retina that interacts with hyaluronan.  |  Acharya, S., et al. 1998. J Biol Chem. 273: 31599-606. PMID: 9813076

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SPACR Antibody (G-11) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-SPACR Antibody (G-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SPACR Antibody (G-11) Specifications

Alternate Product Name: SPACR

Product Clone Name: G-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 121-420

Epitope Target: SPACR

Epitope Species: mouse

Product Reactivity/Detection: SPACR

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for SPACR Antibody (G-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin