SPA-1 Antibody (C-1): sc-137043
- SPA-1 Antibody (C-1) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 691-990 mapping near the C-terminus of SPA-1 of human origin
- recommended for detection of SPA-1 of human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for SPA-1 Antibody (C-1) for WB and IHC(P) applications. These reagents are now offered in bundles with SPA-1 Antibody (C-1) (see ordering information below).
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SEE ALSO...
SPA-1 Antibody (C-1) is a mouse monoclonal IgG1 antibody that detects SPA-1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SPA-1, or signal-induced proliferation-associated gene-1, serves as a crucial regulator of RAP1 GTPase activity, particularly in hematopoietic progenitors and peripheral T cells, where SPA-1 plays a significant role in modulating immune responses. SPA-1 is predominantly located in lymphohematopoietic tissues, both fetal and adult, which is vital for SPA-1′s function in immune cell signaling and proliferation. Notably, SPA-1 expression increases in response to various mitogenic stimuli, highlighting SPA-1′s importance in T cell activation and immune response. Deficiency in SPA-1 leads to age-dependent T cell immunodeficiency and a range of myeloproliferative disorders, resembling chronic myeloid leukemia in humans, underscoring SPA-1′s critical role in maintaining immune homeostasis. Additionally, SPA-1 interacts directly with aquaporin-2 (AQP2), influencing AQP2 trafficking to the apical membrane, which is essential for water regulation in kidney cells. Anti-SPA-1 antibody (C-1) serves as an invaluable tool for researchers studying immune function and related disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SPA-1 Antibody (C-1) | sc-137043 | 200 µg/ml | $322.00 | |||
SPA-1 Antibody (C-1): m-IgG Fc BP-HRP Bundle | sc-539922 | 200 µg Ab; 10 µg BP | $361.00 | |||
SPA-1 Antibody (C-1): m-IgG1 BP-HRP Bundle | sc-541789 | 200 µg Ab; 20 µg BP | $361.00 |