SP17 Antibody (C-3): sc-374507
- SP17 Antibody (C-3) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 41-151 mapping at the C-terminus of SP17 of human origin
- SP17 Antibody (C-3) is recommended for detection of SP17 of human origin by WB, IP, IF and ELISA
- Anti-SP17 Antibody (C-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP is the preferred secondary detection reagent for SP17 Antibody (C-3) for WB applications. This reagent is now offered in a bundle with SP17 Antibody (C-3) (see ordering information below).
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SEE ALSO...
SP17 Antibody (C-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects SP17 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SP17 (C-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SP17, also known as sperm protein 17, SPA17, or cancer/testis antigen 22 (CT22), is a crucial sperm surface peripheral membrane protein predominantly expressed in the testis. SP17 features two heparan binding motifs and a C-terminal calmodulin-binding domain, which are essential for function. SP17 exists as a homodimer and is localized to the head and tail of spermatozoa, where SP17 plays a significant role in fertilization by binding with high affinity to the zona pellucida of the oocyte. Additionally, SP17 is located in the fibrous sheath of the sperm tail, where SP17 interacts with AKAP 3 through its N-terminus, potentially contributing to signaling pathways in a PKA-independent AKAP complex. Notably, SP17 is also recognized as a cancer/testis antigen, with expression observed in ovarian cancer and multiple myeloma, indicating potential as a target for tumor immunotherapy.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SP17 Antibody (C-3) | sc-374507 | 200 µg/ml | $322.00 | |||
SP17 Antibody (C-3): m-IgG2b BP-HRP Bundle | sc-548744 | 200 µg Ab; 10 µg BP | $361.00 | |||
SP17 Antibody (C-3) AC | sc-374507 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SP17 Antibody (C-3) HRP | sc-374507 HRP | 200 µg/ml | $322.00 | |||
SP17 Antibody (C-3) FITC | sc-374507 FITC | 200 µg/ml | $336.00 | |||
SP17 Antibody (C-3) PE | sc-374507 PE | 200 µg/ml | $349.00 | |||
SP17 Antibody (C-3) Alexa Fluor® 488 | sc-374507 AF488 | 200 µg/ml | $364.00 | |||
SP17 Antibody (C-3) Alexa Fluor® 546 | sc-374507 AF546 | 200 µg/ml | $364.00 | |||
SP17 Antibody (C-3) Alexa Fluor® 594 | sc-374507 AF594 | 200 µg/ml | $364.00 | |||
SP17 Antibody (C-3) Alexa Fluor® 647 | sc-374507 AF647 | 200 µg/ml | $364.00 | |||
SP17 Antibody (C-3) Alexa Fluor® 680 | sc-374507 AF680 | 200 µg/ml | $364.00 | |||
SP17 Antibody (C-3) Alexa Fluor® 790 | sc-374507 AF790 | 200 µg/ml | $364.00 |