Sp110 Antibody (JR-16): sc-100770

Sp110 Antibody (JR-16) is a mouse monoclonal IgG2a antibody that detects Sp110 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Sp110, also known as IPR1, VODI, IFI41, or IFI75, is a phosphoprotein that plays a crucial role in the immune response by acting as a transcriptional coactivator of nuclear hormone receptors, thereby influencing gene expression in response to external stimuli such as interferon-gamma and all-trans retinoic acid. Sp110 is primarily located in the nucleus, where Sp110 contributes to the formation of nuclear bodies that are essential for the regulation of gene expression and the immune response. The presence of Sp110 in the nucleus is vital for immunoprotective mechanisms against pathogens, as Sp110 helps modulate the transcriptional activity of genes involved in immune responses. Notably, mutations in the gene encoding Sp110 can lead to hepatic venoocclusive disease with immunodeficiency (VODI), a serious condition characterized by T and B cell immunodeficiency and severe hypogammaglobulinemia. Additionally, Sp110 exists in five isoforms due to alternative splicing, with isoform 3, also known as Sp110b, specifically interacting with the Hepatitis C Core Protein, highlighting Sp110′s potential role in viral pathogenesis. Anti-Sp110 antibody (JR-16) is an invaluable tool for researchers studying immune responses, gene regulation, and related diseases.

The preferred Sp110 antibody is Sp110 Antibody (B-10): sc-376741.