Sp110 Inhibitors
Sp110 inhibitors are a class of chemical compounds designed to specifically target and inhibit the activity of the Sp110 nuclear body protein. Sp110 is part of the SP100 family of proteins and is primarily localized to nuclear bodies within the cell. These nuclear bodies are involved in various processes such as gene regulation, transcriptional control, and immune responses. Sp110, in particular, is known for its role in regulating the transcription of specific genes and influencing chromatin organization. By inhibiting Sp110, researchers can investigate its functional role in controlling gene expression and the maintenance of nuclear architecture. These inhibitors disrupt the interactions and molecular activities of Sp110, allowing for the exploration of its impact on cellular regulation and transcriptional dynamics.
The molecular mechanism by which Sp110 inhibitors function typically involves blocking the protein's key domains, such as those responsible for DNA binding, protein-protein interactions, or its role in chromatin remodeling. These inhibitors may bind to Sp110 in a manner that prevents its localization to nuclear bodies or its association with other regulatory proteins, thereby affecting its capacity to modulate transcriptional processes. Through the use of Sp110 inhibitors, scientists can dissect the protein's involvement in nuclear body formation, gene regulation, and its broader role in cellular homeostasis. These compounds are valuable tools for understanding how Sp110 coordinates with other nuclear proteins to influence gene expression patterns and the structural organization of chromatin, offering insights into the fundamental mechanisms that govern nuclear body function and transcriptional regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By incorporating into genomic DNA, 5-Azacytidine could lead to a reduction in the methylation state of the Sp110 gene promoter, potentially resulting in downregulation of Sp110 transcription. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid may cause hyperacetylation of histones at the Sp110 locus, leading to a condensed chromatin state and subsequent decrease in Sp110 gene transcription. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
By inhibiting DNA methyltransferases, 5-Aza-2′-Deoxycytidine could cause demethylation of the Sp110 gene promoter, which may result in decreased expression of the Sp110 protein. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide might directly bind to transcription factors or coactivators involved in Sp110 gene transcription, leading to a substantial decrease in Sp110 mRNA synthesis. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate could decrease the availability of purines and pyrimidines for DNA synthesis, which may result in a reduced rate of Sp110 gene replication and subsequent expression in dividing cells. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol might downregulate Sp110 expression by inhibiting NF-kB signaling, which could be necessary for the transcription of the Sp110 gene. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may downregulate Sp110 expression by inhibiting the activity of SP1 transcription factor, which is potentially vital for Sp110 gene transcription initiation. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib could lead to the accumulation of ubiquitinated proteins that are involved in the degradation of repressors of Sp110 gene transcription, thereby decreasing Sp110 expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
By inhibiting PI3K, LY 294002 may cause a reduction in AKT phosphorylation and activity, which is implicated in the transcriptional activation of the Sp110 gene, leading to a decrease in its expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin might inhibit mTORC1 signaling, which is potentially involved in the translational control of Sp110 mRNA, resulting in a reduction of Sp110 protein levels. | ||||||