Sox-8 Antibody (H-7): sc-374446
- Sox-8 Antibody (H-7) is a mouse monoclonal IgG1 κ Sox-8 antibody, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 235-271 within an internal region of Sox-8 of human origin
- Sox-8 Antibody (H-7) is recommended for detection of Sox-8 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Sox-8 Antibody (H-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-374446 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Sox-8 Antibody (H-7) for WB applications. These reagents are now offered in bundles with Sox-8 Antibody (H-7) (see ordering information below).
Sox-8 Antibody (H-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects Sox-8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Sox-8 antibody (H-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Sox-8 protein plays a crucial role in regulating gene expression during development, particularly in differentiating various cell types. Sox-8 is primarily located in the nucleus, where Sox-8 functions as a transcription factor, binding to specific DNA sequences to modulate target gene transcription. Nuclear localization enables Sox-8 to interact with other transcriptional regulators and chromatin remodeling complexes, thereby influencing cell fate decisions. Sox gene family, which includes Sox-8, is known for evolutionary conservation and involvement in critical biological functions, including sex determination and central nervous system development. Sox-8 dysregulation has been implicated in various human diseases, highlighting Sox-8′s importance in both normal physiology and pathology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Sox-8 Antibody (H-7) References:
- Identification of a novel Sry-related gene and its germ cell-specific expression. | Osaki, E., et al. 1999. Nucleic Acids Res. 27: 2503-10. PMID: 10359848
- Roles of Sox factors in neural determination: conserved signaling in evolution? | Sasai, Y. 2001. Int J Dev Biol. 45: 321-6. PMID: 11291862
- Ancestry and diversity of the HMG box superfamily. | Laudet, V., et al. 1993. Nucleic Acids Res. 21: 2493-501. PMID: 8506143
- Sox10, a novel transcriptional modulator in glial cells. | Kuhlbrodt, K., et al. 1998. J Neurosci. 18: 237-50. PMID: 9412504
- Characterisation and mapping of the human SOX14 gene. | Arsic, N., et al. 1998. Cytogenet Cell Genet. 83: 139-46. PMID: 9925951
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sox-8 Antibody (H-7) | sc-374446 | 200 µg/ml | $322.00 | |||
Sox-8 Antibody (H-7): m-IgG Fc BP-HRP Bundle | sc-529746 | 200 µg Ab; 10 µg BP | $361.00 | |||
Sox-8 Antibody (H-7): m-IgGκ BP-HRP Bundle | sc-522741 | 200 µg Ab, 40 µg BP | $361.00 | |||
Sox-8 Antibody (H-7): m-IgG1 BP-HRP Bundle | sc-543668 | 200 µg Ab; 20 µg BP | $361.00 | |||
Sox-8 Antibody (H-7) X | sc-374446 X | 200 µg/0.1 ml | $322.00 | |||
Sox-8 Antibody (H-7) AC | sc-374446 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Sox-8 Antibody (H-7) HRP | sc-374446 HRP | 200 µg/ml | $322.00 | |||
Sox-8 Antibody (H-7) FITC | sc-374446 FITC | 200 µg/ml | $336.00 | |||
Sox-8 Antibody (H-7) PE | sc-374446 PE | 200 µg/ml | $349.00 | |||
Sox-8 Antibody (H-7) Alexa Fluor® 488 | sc-374446 AF488 | 200 µg/ml | $364.00 | |||
Sox-8 Antibody (H-7) Alexa Fluor® 546 | sc-374446 AF546 | 200 µg/ml | $364.00 | |||
Sox-8 Antibody (H-7) Alexa Fluor® 594 | sc-374446 AF594 | 200 µg/ml | $364.00 | |||
Sox-8 Antibody (H-7) Alexa Fluor® 647 | sc-374446 AF647 | 200 µg/ml | $364.00 | |||
Sox-8 Antibody (H-7) Alexa Fluor® 680 | sc-374446 AF680 | 200 µg/ml | $364.00 | |||
Sox-8 Antibody (H-7) Alexa Fluor® 790 | sc-374446 AF790 | 200 µg/ml | $364.00 | |||
Sox-8 (H-7) Neutralizing Peptide | sc-374446 P | 100 µg/0.5 ml | $69.00 |