Sox-3 Antibody (16-C2): sc-101155

Sox-3 Antibody (16-C2) is a mouse monoclonal IgG2a kappa light chain antibody that detects Sox-3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Sox-3 (16-C2) antibody is available as a non-conjugated isotype antibody. Sox-3 protein, also known as MRGH or SOXB, plays a crucial role in regulating gene expression during development, particularly in sex determination and neurogenesis. Sox-3 is located primarily in the nucleus, functioning as a transcription factor that binds to specific DNA sequences, influencing the expression of target genes essential for cell fate decisions. Nuclear localization allows Sox-3 to interact with other transcriptional regulators and chromatin remodeling complexes, orchestrating complex developmental processes. Dysregulation of Sox-3 has been linked to various human disorders, including mental retardation X-linked with isolated growth hormone deficiency and hypopituitarism, highlighting Sox-3′s importance in both normal development and disease. With detection capabilities across multiple species, anti-Sox-3 antibody (16-C2) serves as an invaluable tool for researchers studying developmental biology and related pathologies.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Sox-3 Antibody (16-C2) References:

1. Identification of a novel Sry-related gene and its germ cell-specific expression.  |  Osaki, E., et al. 1999. Nucleic Acids Res. 27: 2503-10. PMID: 10359848
2. A heuristic approach of maximum likelihood method for inferring phylogenetic tree and an application to the mammalian SOX-3 origin of the testis-determining gene SRY.  |  Katoh, K. and Miyata, T. 1999. FEBS Lett. 463: 129-32. PMID: 10601652
3. Roles of Sox factors in neural determination: conserved signaling in evolution?  |  Sasai, Y. 2001. Int J Dev Biol. 45: 321-6. PMID: 11291862
4. Identification and expression of a new sulfhydryl oxidase SOx-3 during the cell cycle and the estrus cycle in uterine cells.  |  Musard, JF., et al. 2001. Biochem Biophys Res Commun. 287: 83-91. PMID: 11549257
5. A new 6-bp SOX-3 polyalanine tract deletion does not segregate with mental retardation.  |  Salemi, M., et al. 2007. Genet Test. 11: 124-7. PMID: 17627381
6. C. elegans SoxB genes are dispensable for embryonic neurogenesis but required for terminal differentiation of specific neuron types.  |  Vidal, B., et al. 2015. Development. 142: 2464-77. PMID: 26153233
7. The effect of high Sox3 expression on lymphangiogenesis and lymph node metastasis in esophageal squamous cell carcinoma.  |  Zheng, YF., et al. 2017. Am J Transl Res. 9: 2684-2693. PMID: 28670361
8. The zebrafish Zf-Sox 19 protein: a novel member of the Sox family which reveals highly conserved motifs outside of the DNA-binding domain.  |  Vriz, S. and Lovell-Badge, R. 1995. Gene. 153: 275-6. PMID: 7875601
9. Ancestry and diversity of the HMG box superfamily.  |  Laudet, V., et al. 1993. Nucleic Acids Res. 21: 2493-501. PMID: 8506143
10. A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2.  |  Collignon, J., et al. 1996. Development. 122: 509-20. PMID: 8625802
11. Sox10, a novel transcriptional modulator in glial cells.  |  Kuhlbrodt, K., et al. 1998. J Neurosci. 18: 237-50. PMID: 9412504
12. Characterisation and mapping of the human SOX14 gene.  |  Arsic, N., et al. 1998. Cytogenet Cell Genet. 83: 139-46. PMID: 9925951

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Sox-3 Antibody (16-C2) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Sox-3 Antibody (16-C2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Sox-3 Antibody (16-C2) Specifications

Alternate Product Name: SOX3

Product Clone Name: 16-C2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 375-446

Epitope Target: Sox-3

Epitope Species: human

Product Reactivity/Detection: Sox-3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Sox-3 Antibody (16-C2): N/A