Sox-18 Antibody (E-2): sc-166670

Sox-18 Antibody (E-2) is a mouse monoclonal IgG2b antibody that detects Sox-18 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Sox-18 is a crucial nuclear protein composed of 384 amino acids, featuring a single HMG box DNA-binding domain, which is essential for Sox-18′s role as a transcriptional regulator within the Sox gene family. Sox family members are known for involvement in critical developmental processes and cell fate determination, making anti-Sox-18 antibody (E-2) particularly significant in studying embryonic development and differentiation. Sox-18′s ability to bind specific DNA sequences allows regulation of target gene expression, influencing various biological pathways. Sox-18 has been implicated in vascular system development and hair follicle formation, highlighting Sox-18′s importance in both normal physiology and potential disease states. Sox-18 interacts with other transcription factors and regulatory proteins, which can modulate activity and impact downstream signaling pathways, underscoring the complexity of Sox-18′s regulatory network. Conservation of Sox genes throughout evolution emphasizes fundamental roles in developmental biology, and studying Sox-18 (E-2) monoclonal antibody can provide insights into both normal development and mechanisms underlying certain human diseases, including those related to sex determination and vascular anomalies.

The preferred Sox-18 antibody is Sox-18 Antibody (D-8): sc-166025.