Sox-15 Antibody (D-8): sc-166966

Sox-15 Antibody (D-8) is a mouse monoclonal IgG1 antibody that detects Sox-15 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Sox-15 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which are crucial for regulating embryonic development and determining cell fate. Sox-15 is primarily located in the nucleus, where Sox-15 plays a vital role in gene expression regulation, influencing processes such as cell differentiation and sex determination. Nuclear localization of Sox-15 allows for precise control of developmental pathways, ensuring cells adopt correct identities during embryogenesis. Additionally, Sox-15 contains a high mobility group (HMG) box, a unique DNA-binding domain that facilitates interaction with specific DNA sequences, thereby modulating transcription of target genes. This DNA-binding ability and gene expression regulation underscores Sox-15′s importance in developmental biology and potential implications in understanding various diseases linked to developmental disorders. Sox-15 (D-8) antibody is widely expressed in fetal and adult tissues, with highest levels found in fetal spinal cord, adult brain, and adult testis, making Sox-15 (D-8) monoclonal antibody a valuable tool for researchers studying Sox-15′s roles in different biological contexts.

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Sox-15 Antibody (D-8) References:

1. Sox15 is required for skeletal muscle regeneration.  |  Lee, HJ., et al. 2004. Mol Cell Biol. 24: 8428-36. PMID: 15367664
2. Function and molecular evolution of mammalian Sox15, a singleton in the SoxG group of transcription factors.  |  Ito, M. 2010. Int J Biochem Cell Biol. 42: 449-52. PMID: 19909824
3. SOX15 regulates proliferation and migration of endometrial cancer cells.  |  Rui, X., et al. 2017. Biosci Rep. 37: PMID: 28821564
4. Effects of SOX15 on the colorectal cancer cells via downregulation of the Wnt/β-catenin signaling pathway.  |  Wang, S., et al. 2018. Future Oncol. 14: 1921-1932. PMID: 30019915
5. Inhibition of SOX15 Sensitizes Esophageal Squamous Carcinoma Cells to Paclitaxel.  |  Zhang, M., et al. 2019. Curr Mol Med. 19: 349-356. PMID: 30950353
6. Testing the role of SOX15 in human primordial germ cell fate.  |  Pierson Smela, M., et al. 2019. Wellcome Open Res. 4: 122. PMID: 31583280
7. SOX15 exerts antitumor function in glioma by inhibiting cell proliferation and invasion via downregulation of Wnt/β-catenin signaling.  |  Zhang, D., et al. 2020. Life Sci. 255: 117792. PMID: 32416168
8. Independent pseudogenizations and losses of sox15 during amniote diversification following asymmetric ohnolog evolution.  |  Ogita, Y., et al. 2021. BMC Ecol Evol. 21: 134. PMID: 34193037
9. SOX15 transcriptionally increases the function of AOC1 to modulate ferroptosis and progression in prostate cancer.  |  Ding, Y., et al. 2022. Cell Death Dis. 13: 673. PMID: 35922412
10. Transcription factor SOX15 regulates stem cell pluripotency and promotes neural fate during differentiation by activating the neurogenic gene Hes5.  |  Choi, EB., et al. 2023. J Biol Chem. 299: 102996. PMID: 36764520

The preferred Sox-15 antibody is Sox-15 Antibody (C-7): sc-166964.