Sox-15 Antibody (C-7): sc-166964

Sox-15 Antibody (C-7) is a mouse monoclonal IgM antibody that detects Sox-15 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Sox-15 (C-7) antibody is available as the non-conjugated form. Sox-15 protein, also known as SRY-related HMG-box transcription factor 15, plays a crucial role in embryonic development and cell fate determination by acting as a transcriptional regulator. Sox-15 achieves this by forming protein complexes with other transcription factors, which is essential for the precise regulation of gene expression during development. Sox-15 is predominantly expressed in fetal and adult tissues, with the highest levels found in the fetal spinal cord, adult brain, and adult testis, highlighting Sox-15′s importance in both early and later stages of development. Sox-15 contains a distinctive high mobility group (HMG) box DNA binding domain, which is critical for function and is related to the testis-determining gene SRY. The Sox family of transcription factors, including Sox-15, is known for influencing cell differentiation, development, and sex determination, and evolutionary conservation underscores fundamental roles in animal development. With an ability to interact with various proteins, Sox-15 is integral to the complex regulatory networks that govern cellular processes, making anti-Sox-15 antibody (C-7) a valuable tool for researchers studying these critical biological functions.

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Sox-15 Antibody (C-7) References:

1. Identification of a novel Sry-related gene and its germ cell-specific expression.  |  Osaki, E., et al. 1999. Nucleic Acids Res. 27: 2503-10. PMID: 10359848
2. Roles of Sox factors in neural determination: conserved signaling in evolution?  |  Sasai, Y. 2001. Int J Dev Biol. 45: 321-6. PMID: 11291862
3. The cross-regulation between SOX15 and Wnt signaling pathway.  |  Moradi, A., et al. 2017. J Cell Physiol. 232: 3221-3225. PMID: 28092101
4. Sox15 Methylation Inhibits Cell Proliferation Through Wnt Signaling in Hepatocellular Carcinoma.  |  Wei, B., et al. 2022. Front Oncol. 12: 842312. PMID: 35392235
5. Sox 15, a novel member of the murine Sox family of HMG box transcription factors.  |  van de Wetering, M. and Clevers, H. 1993. Nucleic Acids Res. 21: 1669. PMID: 8479922
6. Ancestry and diversity of the HMG box superfamily.  |  Laudet, V., et al. 1993. Nucleic Acids Res. 21: 2493-501. PMID: 8506143
7. SOX20, a new member of the SOX gene family, is located on chromosome 17p13.  |  Meyer, J., et al. 1996. Cytogenet Cell Genet. 72: 246-9. PMID: 8978787
8. Sox10, a novel transcriptional modulator in glial cells.  |  Kuhlbrodt, K., et al. 1998. J Neurosci. 18: 237-50. PMID: 9412504
9. Isolation and expression of a human SRY-related cDNA hSOX20.  |  Hiraoka, Y., et al. 1998. Biochim Biophys Acta. 1396: 132-7. PMID: 9540826
10. Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3.  |  Critcher, R., et al. 1998. Cytogenet Cell Genet. 81: 294-5. PMID: 9730625
11. cDNA characterization and high resolution mapping of the human SOX20 gene.  |  Vujić, M., et al. 1998. Mamm Genome. 9: 1059-61. PMID: 9880678
12. Characterisation and mapping of the human SOX14 gene.  |  Arsic, N., et al. 1998. Cytogenet Cell Genet. 83: 139-46. PMID: 9925951

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Sox-15 Antibody (C-7) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Sox-15 Antibody (C-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Sox-15 Antibody (C-7) Specifications

Alternate Product Name: SOX15

Product Clone Name: C-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 2-21

Epitope Target: Sox-15

Epitope Species: human

Product Reactivity/Detection: Sox-15

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Sox-15 Antibody (C-7): P: Blocking Peptide, X: TransCruz Reagent