Sororin Antibody (D-11): sc-390900

Sororin Antibody (D-11) is a mouse monoclonal IgG1 antibody that detects Sororin in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Sororin, also known as cell division cycle-associated protein 5 (CDCA5) or p35, plays a crucial role in regulating sister chromatid cohesion during mitosis, which is essential for accurate chromosome segregation and maintaining genomic stability. Anti-Sororin antibody (D-11) interacts with the anaphase-promoting complex/cyclosome (APC/C) and is part of a larger complex that includes cohesion components such as SCC-112, MC1L1, SMC3L1, RAD21, and APRIN. Sororin protein is composed of 252 amino acids in humans and 264 amino acids in mice, both featuring a KEN box that is vital for APC-dependent ubiquitination, a post-translational modification that regulates protein degradation and function. Notably, Sororin exhibits a punctate distribution in the nucleus during interphase, transitioning to a more diffuse pattern throughout the cell during mitosis, indicating its dynamic role in cell cycle regulation. The Sororin gene is located on chromosome 11q12.1, and Sororin expression levels decrease in synchronized HeLa cells during interphase, highlighting its tightly regulated expression during the cell cycle. Sororin monoclonal antibody (D-11) is an invaluable tool for researchers studying cell division and chromosomal dynamics.

The preferred Sororin antibody is Sororin Antibody (B-9): sc-365319.