Superoxide Dismutase 3/SOD3 Antibody (4G11G6): sc-101338

SOD-3 Antibody (4G11G6) is a mouse monoclonal IgG1 antibody that detects superoxide dismutase-3 (SOD-3) in mouse, rat, and human samples through applications such as western blotting (WB), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). SOD-3, also known as extracellular superoxide dismutase, plays a crucial role in protecting tissues from oxidative stress by catalyzing the dismutation of superoxide radicals into hydrogen peroxide and oxygen, thereby mitigating cellular damage caused by reactive oxygen species. Anti-SOD-3 antibody (4G11G6) enables detection of this protein in extracellular fluids, including lymph, plasma, and synovial fluid, where SOD-3 helps neutralize free radicals that can lead to inflammation and tissue injury. SOD-3′s presence in these fluids underscores its significance in maintaining cellular homeostasis and preventing oxidative damage, which is linked to various pathological conditions, including cardiovascular diseases and neurodegenerative disorders. SOD-3 (4G11G6) monoclonal antibody serves as an essential tool for researchers studying oxidative stress and its implications in health and disease, providing reliable detection and characterization of this vital enzyme in various biological contexts.

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Superoxide Dismutase 3/SOD3 Antibody (4G11G6) References:

1. Superoxide dismutase 3, extracellular (SOD3) variants and lung function.  |  Ganguly, K., et al. 2009. Physiol Genomics. 37: 260-7. PMID: 19318538
2. Carbon monoxide-releasing molecule CORM-3 suppresses vascular endothelial cell SOD-1/SOD-2 activity while up-regulating the cell surface levels of SOD-3 in a heparin-dependent manner.  |  Mizuguchi, S., et al. 2010. Free Radic Biol Med. 49: 1534-41. PMID: 20797432
3. SOD3 acts as a tumor suppressor in PC-3 prostate cancer cells via hydrogen peroxide accumulation.  |  Kim, J., et al. 2014. Anticancer Res. 34: 2821-31. PMID: 24922645
4. The R213G polymorphism in SOD3 protects against allergic airway inflammation.  |  Gaurav, R., et al. 2017. JCI Insight. 2: PMID: 28878123
5. Extracellular superoxide dismutase (SOD3) regulates oxidative stress at the vitreoretinal interface.  |  Wert, KJ., et al. 2018. Free Radic Biol Med. 124: 408-419. PMID: 29940351
6. Exercise improves angiogenic function of circulating exosomes in type 2 diabetes: Role of exosomal SOD3.  |  Abdelsaid, K., et al. 2022. FASEB J. 36: e22177. PMID: 35142393
7. The Effect of Extracellular Superoxide Dismutase (SOD3) Gene in Lung Cancer.  |  Zhang, Y., et al. 2022. Front Oncol. 12: 722646. PMID: 35356201
8. SOD3 and IL-18 Predict the First Kidney Disease-Related Hospitalization or Death during the One-Year Follow-Up Period in Patients with End-Stage Renal Disease.  |  Liu, YH., et al. 2022. Antioxidants (Basel). 11: PMID: 35740095
9. Potential Role of Superoxide Dismutase 3 (SOD3) in Resistance to Influenza A Virus Infection.  |  Chen, F., et al. 2023. Antioxidants (Basel). 12: PMID: 36829913
10. Changes in superoxide dismutase 3 (SOD3) expression in periodontal tissue during orthodontic tooth movement of rat molars and the effect of SOD3 on in vitro hypoxia-exposed rat periodontal ligament cells.  |  Jindarojanakul, P., et al. 2023. Eur J Orthod. 45: 430-437. PMID: 36989187

The preferred Superoxide Dismutase 3/SOD3 antibody is Superoxide Dismutase 3/SOD3 Antibody (G-11): sc-376948.