Superoxide Dismutase 1/SOD1 Antibody (24): sc-101523

SOD-1 Antibody (24) is a mouse monoclonal IgG1 kappa light chain antibody that detects SOD-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-SOD-1 antibody (24) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Cu-Zn superoxide dismutase-1 (SOD-1) protein plays a crucial role in cellular defense against oxidative stress by catalyzing the dismutation of superoxide radicals into hydrogen peroxide and molecular oxygen, thereby protecting cells from damage caused by reactive oxygen species. This enzymatic activity is vital for maintaining cellular homeostasis, particularly in tissues with high metabolic rates, such as the brain and muscles. SOD-1 is predominantly located in the cytosol and functions as a homodimer, which is essential for stability and activity. Mutations in the SOD-1 gene have been linked to severe neurological disorders, including amyotrophic lateral sclerosis (ALS), where the loss of antioxidant function leads to increased oxidative damage and neurodegeneration. Understanding SOD-1 and its interactions with other proteins involved in oxidative stress response is critical for developing therapeutic strategies against these debilitating diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Superoxide Dismutase 1/SOD1 Antibody (24) has 105 citations in a variety of scientific publications.

Primary antibodies like Anti-Superoxide Dismutase 1/SOD1 Antibody (24) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Superoxide Dismutase 1/SOD1 Antibody (24) Specifications

Alternate Product Name: SOD1

Product Clone Name: 24

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: SOD-1

Epitope Species: human

Product Reactivity/Detection: SOD-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 105 citations in various scientific publications

Available Conjugates/Forms for Superoxide Dismutase 1/SOD1 Antibody (24): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Superoxide Dismutase 1/SOD1 antibody is Superoxide Dismutase 1/SOD1 Antibody (B-1): sc-271014.