SOCS-6 Antibody (B-11): sc-133058
- SOCS-6 Antibody (B-11) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 132-382 of SOCS-6 of human origin
- recommended for detection of SOCS-6 of human origin by WB, IP, IF and ELISA
- m-IgG1 BP-HRP is the preferred secondary detection reagent for SOCS-6 Antibody (B-11) for WB applications. This reagent is now offered in a bundle with SOCS-6 Antibody (B-11) (see ordering information below).
SOCS-6 Antibody (B-11) is a mouse monoclonal IgG1 antibody that detects SOCS-6 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SOCS-6 is a member of the suppressor of cytokine signaling (SOCS) family, which plays a crucial role in the negative regulation of cytokine signal transduction, thereby maintaining cellular homeostasis and preventing excessive inflammatory responses. SOCS-6 is primarily located in the cytoplasm, where SOCS-6 interacts with various signaling pathways, including those activated by interleukin-6 and other cytokines. The cytoplasmic localization of SOCS-6 is significant because SOCS-6 allows for the timely modulation of signaling cascades, ensuring that cellular responses to cytokines are appropriately regulated. Dysregulation of SOCS-6 expression can lead to pathological conditions, including autoimmune diseases and cancer, highlighting SOCS-6′s importance in maintaining immune system balance. Anti-SOCS-6 antibody (B-11) is an essential tool for researchers studying the intricate mechanisms of cytokine signaling and its implications in health and disease.
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SOCS-6 Antibody (B-11) References:
- SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation. | Choi, YB., et al. 2010. J Biol Chem. 285: 7271-80. PMID: 20007709
- Suppressor of cytokine signaling 6 (SOCS6) promotes mitochondrial fission via regulating DRP1 translocation. | Lin, HY., et al. 2013. Cell Death Differ. 20: 139-53. PMID: 22955947
- Identification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer. | Letellier, E., et al. 2014. Br J Cancer. 111: 726-35. PMID: 25025962
- SOCS6 is a selective suppressor of receptor tyrosine kinase signaling. | Kabir, NN., et al. 2014. Tumour Biol. 35: 10581-9. PMID: 25172101
- SOCS6 Functions as a Tumor Suppressor by Inducing Apoptosis and Inhibiting Angiogenesis in Human Prostate Cancer. | Yuan, D., et al. 2018. Curr Cancer Drug Targets. 18: 894-904. PMID: 29295692
- Inhibition of SOCS6 confers radioresistance in esophageal squamous cell carcinoma. | Ma, R., et al. 2021. Biochem Biophys Res Commun. 550: 92-98. PMID: 33689885
- Circ_0085289 Alleviates the Progression of Periodontitis by Regulating let-7f-5p/SOCS6 Pathway. | Du, W., et al. 2021. Inflammation. 44: 1607-1619. PMID: 33710445
- Inhibition of miR-1298-5p attenuates sepsis lung injury by targeting SOCS6. | Ma, J., et al. 2021. Mol Cell Biochem. 476: 3745-3756. PMID: 34100174
- Down-regulation of SOCS6: an unfavorable prognostic factor for gastrointestinal stromal tumor proven by survival analysis. | Ouyang, J., et al. 2021. Diagn Pathol. 16: 113. PMID: 34895274
- Serum levels of SOCS6 are decreased in diabetic retinopathy and are related to severity of the disease. | Li, L., et al. 2023. Adv Clin Exp Med. 32: 873-880. PMID: 37589228
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SOCS-6 Antibody (B-11) | sc-133058 | 200 µg/ml | $322.00 | |||
SOCS-6 Antibody (B-11): m-IgG1 BP-HRP Bundle | sc-542638 | 200 µg Ab; 20 µg BP | $361.00 |