SOCS-6 Antibody (G-3): sc-74597

SOCS-6 Antibody (G-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects SOCS-6 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SOCS-6 (G-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SOCS-6 plays a crucial role in the negative regulation of cytokine signaling pathways, which is vital for maintaining cellular homeostasis and preventing excessive inflammatory responses. Located primarily in the cytoplasm, SOCS-6 interacts with various signaling molecules, thereby modulating the activity of key pathways such as the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. This regulation is essential for controlling immune responses and ensuring that cytokine signaling does not lead to pathological conditions such as chronic inflammation or autoimmune diseases. The structure of SOCS-6 includes a central SH2 domain and a SOCS box, which are critical for its function in protein-protein interactions and subsequent signaling modulation. Using anti-SOCS-6 antibody (G-3) in research can provide valuable insights into the mechanisms of cytokine signaling and its implications in various diseases.

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SOCS-6 Antibody (G-3) References:

1. Increased SOCS6 stability with PMA requires its N-terminal region and the Erk pathway via Pkcdelta activation.  |  Hwang, MN., et al. 2007. Biochem Biophys Res Commun. 354: 184-9. PMID: 17210122
2. SOCS5 and SOCS6 have similar expression patterns in normal and cancer tissues.  |  Yoon, S., et al. 2012. Tumour Biol. 33: 215-21. PMID: 22081311
3. Suppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyrosines 591 and 919 of Flt3.  |  Kazi, JU., et al. 2012. J Biol Chem. 287: 36509-17. PMID: 22952242
4. MicroRNA-424-5p suppresses the expression of SOCS6 in pancreatic cancer.  |  Wu, K., et al. 2013. Pathol Oncol Res. 19: 739-48. PMID: 23653113
5. miR-19 promotes osteosarcoma progression by targeting SOCS6.  |  Sun, Z., et al. 2018. Biochem Biophys Res Commun. 495: 1363-1369. PMID: 28986253
6. MicroRNA-494-3p Exacerbates Renal Epithelial Cell Dysfunction by Targeting SOCS6 under High Glucose Treatment.  |  Xue, X., et al. 2022. Kidney Blood Press Res. 47: 247-255. PMID: 35038704
7. Circ_0062491 alleviates LPS-induced apoptosis and inflammation in periodontitis by regulating miR-498/SOCS6 axis.  |  Wang, L., et al. 2022. Innate Immun. 28: 174-184. PMID: 35678490
8. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.  |  Yoshimura, A., et al. 1995. EMBO J. 14: 2816-26. PMID: 7796808
9. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation.  |  Matsumoto, A., et al. 1997. Blood. 89: 3148-54. PMID: 9129017
10. A family of cytokine-inducible inhibitors of signalling.  |  Starr, R., et al. 1997. Nature. 387: 917-21. PMID: 9202125
11. Twenty proteins containing a C-terminal SOCS box form five structural classes.  |  Hilton, DJ., et al. 1998. Proc Natl Acad Sci U S A. 95: 114-9. PMID: 9419338
12. The SOCS proteins: a new family of negative regulators of signal transduction.  |  Nicholson, SE. and Hilton, DJ. 1998. J Leukoc Biol. 63: 665-8. PMID: 9620657

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SOCS-6 Antibody (G-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SOCS-6 Antibody (G-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SOCS-6 Antibody (G-3) Specifications

Alternate Product Name: SOCS-6

Product Clone Name: G-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 132-382

Epitope Target: SOCS-6

Epitope Species: human

Product Reactivity/Detection: SOCS-6

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SOCS-6 Antibody (G-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin