SOCS-4 Antibody (9J12): sc-135566

SOCS-4 Antibody (9J12) is a mouse monoclonal IgG2b kappa light chain antibody that detects the SOCS-4 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SOCS-4 antibody (9J12) is available as a non-conjugated format. SOCS-4, also known as suppressor of cytokine signaling 4 or SOCS7, is a crucial component in the regulation of cytokine signaling pathways, playing a significant role in modulating immune responses and inflammation. This 440 amino acid protein features one SH2 domain and one SOCS box domain, with the latter being essential for interaction with the Elongin B/C complex, vital for E3 ubiquitin-protein ligase activity. Through mediating ubiquitination and subsequent proteasomal degradation of target proteins, SOCS-4 maintains cellular homeostasis and prevents excessive signaling that could lead to pathological conditions. SOCS-4′s regulation of these processes underscores its importance in various biological contexts, including immune regulation and prevention of chronic inflammatory diseases.

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SOCS-4 Antibody (9J12) References:

1. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.  |  Zhang, JG., et al. 1999. Proc Natl Acad Sci U S A. 96: 2071-6. PMID: 10051596
2. The suppressors of cytokine signalling (SOCS).  |  Kile, BT. and Alexander, WS. 2001. Cell Mol Life Sci. 58: 1627-35. PMID: 11706989
3. The SOCS box: a tale of destruction and degradation.  |  Kile, BT., et al. 2002. Trends Biochem Sci. 27: 235-41. PMID: 12076535
4. Suppressors of cytokine signalling: SOCS.  |  Larsen, L. and Röpke, C. 2002. APMIS. 110: 833-44. PMID: 12645661
5. Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.  |  Kario, E., et al. 2005. J Biol Chem. 280: 7038-48. PMID: 15590694
6. Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation.  |  Bullock, AN., et al. 2007. Structure. 15: 1493-504. PMID: 17997974
7. The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.  |  Kamura, T., et al. 1998. Genes Dev. 12: 3872-81. PMID: 9869640

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SOCS-4 Antibody (9J12) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-SOCS-4 Antibody (9J12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SOCS-4 Antibody (9J12) Specifications

Alternate Product Name: SOCS-4

Product Clone Name: 9J12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-441

Epitope Target: SOCS-4

Epitope Species: human

Product Reactivity/Detection: SOCS-4

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for SOCS-4 Antibody (9J12): N/A

The preferred SOCS-4 antibody is SOCS-4 Antibody (F-1): sc-518223.