SO Antibody (G-4): sc-390322

SO Antibody (G-4) is a mouse monoclonal IgG2b antibody that detects sulfite oxidase (SO) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SO is a crucial homodimeric enzyme located in the intermembrane space of mitochondria, where SO catalyzes the oxidation of sulfite to sulfate, marking the final step in the oxidative degradation of sulfur-containing amino acids such as cysteine and methionine. SO (G-4) antibody aids in studying proper functioning of SO, which is vital for maintaining sulfur amino acid homeostasis, as deficiencies can lead to severe neurological disorders and early mortality. Notably, mutations in the Arginine 160 residue significantly impair the intramolecular electron transfer rate, exacerbating the severity of related genetic conditions. Additionally, the tyrosine 343 residue is essential for both substrate binding and the oxidation process, highlighting the intricate nature of SO′s structure and functional implications. The human SO gene is located on chromosome 12 and exhibits high expression levels in critical tissues, including the liver, kidney, skeletal muscle, heart, placenta, and brain, underscoring SO′s importance in various physiological processes. Anti-SO antibody (G-4) serves as an invaluable tool for researchers investigating sulfite oxidase in health and disease.

The preferred SO antibody is SO Antibody (F-6): sc-393688.