SO Antibody (G-1): sc-390323

SO Antibody (G-1) is a mouse monoclonal IgG1 antibody that detects sulfite oxidase in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-sulfite oxidase antibody (G-1) targets sulfite oxidase, a crucial homodimeric enzyme located in the intermembrane space of mitochondria, where sulfite oxidase plays a vital role in the oxidative degradation of sulfur amino acids such as cysteine and methionine by catalyzing the conversion of sulfite to sulfate. This enzymatic activity is essential for maintaining sulfur metabolism and preventing the accumulation of toxic sulfite levels, which can lead to severe neurological disorders when sulfite oxidase is deficient. Notably, mutations in the sulfite oxidase gene, particularly at the Arginine 160 position, can significantly impair intramolecular electron transfer, exacerbating the severity of related genetic disorders. Additionally, the tyrosine 343 residue is critical for both substrate binding and the oxidation process, highlighting the intricate structure-function relationship of sulfite oxidase. The human sulfite oxidase gene is located on chromosome 12 and exhibits high expression levels in key tissues such as the liver, kidney, skeletal muscle, heart, placenta, and brain, underscoring sulfite oxidase′s importance in various physiological processes.

The preferred SO antibody is SO Antibody (F-6): sc-393688.