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SNX6 Antibody (D-1): sc-365795

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Datasheets
  • SNX6 Antibody (D-1) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
  • raised against amino acids 1-40 mapping at the N-terminus of SNX6 of human origin
  • recommended for detection of SNX6 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
  • m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for SNX6 Antibody (D-1) for WB applications. These reagents are now offered in bundles with SNX6 Antibody (D-1) (see ordering information below).

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SNX6 Antibody (D-1) is a mouse monoclonal IgG2a antibody that detects SNX6 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SNX6, also known as sorting nexin 6, plays a crucial role in intracellular trafficking and sorting of membrane proteins, which is essential for maintaining cellular homeostasis and signaling pathways. SNX6 is primarily located in the endosomal compartments of the cell, where SNX6 interacts with various receptors and contributes to the regulation of endocytosis and recycling processes. The proper functioning of SNX6 is vital, as disruptions in SNX6 activity can lead to impaired receptor signaling and have been implicated in various diseases, including cancer and neurodegenerative disorders. Anti-SNX6 antibody (D-1) provides a reliable tool for researchers aiming to study the dynamics of protein sorting and trafficking, offering insights into the molecular mechanisms underlying cellular function and disease progression.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

SNX6 Antibody (D-1) References:

  1. A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer.  |  Wassmer, T., et al. 2007. J Cell Sci. 120: 45-54. PMID: 17148574
  2. The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport.  |  Hong, Z., et al. 2009. Cell Res. 19: 1334-49. PMID: 19935774
  3. Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression.  |  Rivera, J., et al. 2010. J Cell Biochem. 111: 1464-72. PMID: 20830743
  4. The structure of BRMS1 nuclear export signal and SNX6 interacting region reveals a hexamer formed by antiparallel coiled coils.  |  Spínola-Amilibia, M., et al. 2011. J Mol Biol. 411: 1114-27. PMID: 21777593
  5. Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope.  |  González-Granado, JM., et al. 2014. PLoS One. 9: e115571. PMID: 25535984
  6. miR-98-5p Acts as a Target for Alzheimer's Disease by Regulating Aβ Production Through Modulating SNX6 Expression.  |  Li, Q., et al. 2016. J Mol Neurosci. 60: 413-420. PMID: 27541017
  7. Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory.  |  Niu, Y., et al. 2017. Elife. 6: PMID: 28134614
  8. SNX6 predicts poor prognosis and contributes to the metastasis of pancreatic cancer cells via activating epithelial-mesenchymal transition.  |  Hu, P., et al. 2018. Acta Biochim Biophys Sin (Shanghai). 50: 1075-1084. PMID: 30307473
  9. Pb exposure reduces the expression of SNX6 and Homer1 in offspring rats and PC12 cells.  |  Pang, S., et al. 2019. Toxicology. 416: 23-29. PMID: 30738087
  10. Sorting nexin 6 interacts with Cullin3 and regulates programmed death ligand 1 expression.  |  Ghosh, C., et al. 2021. FEBS Lett. 595: 2558-2569. PMID: 34510437

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

SNX6 Antibody (D-1)

sc-365795
200 µg/ml
$316.00

SNX6 Antibody (D-1): m-IgG Fc BP-HRP Bundle

sc-540370
200 µg Ab; 10 µg BP
$354.00

SNX6 Antibody (D-1): m-IgG2a BP-HRP Bundle

sc-546897
200 µg Ab; 10 µg BP
$354.00

Are there any issues with using sc-365795: SNX6 (D-1) mouse monoclonal primary antibody on mouse samples?

Asked by: Randy McDonald
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-365795 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
  • y_2025, m_10, d_14, h_6CST
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Rated 5 out of 5 by from Produced nice Western blot data of SNX6 expressionProduced nice Western blot data of SNX6 expression in LADMAC whole cell lysate. -SCBT QC
Date published: 2013-05-31
  • y_2025, m_10, d_14, h_6
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SNX6 Antibody (D-1) is rated 5.0 out of 5 by 1.
  • y_2025, m_10, d_14, h_6
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  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
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