SNX6 Antibody (D-5): sc-365965

SNX6 Antibody (D-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects SNX6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-SNX6 antibody (D-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SNX6 plays a crucial role in intracellular trafficking and sorting of membrane proteins, which is essential for maintaining cellular homeostasis and signaling pathways. By facilitating receptor recycling and degradation, SNX6 helps regulate protein availability on the cell surface, thereby influencing cellular responses to external stimuli. SNX6 interacts with several other proteins, including TRAF1 and TRAF2, which are involved in tumor necrosis factor receptor signaling pathways. Understanding SNX6 function and interactions is vital for elucidating its role in various physiological processes and potential implications in diseases where receptor signaling is disrupted.

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SNX6 Antibody (D-5) References:

1. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases.  |  Parks, WT., et al. 2001. J Biol Chem. 276: 19332-9. PMID: 11279102
2. Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus.  |  Ishibashi, Y., et al. 2001. FEBS Lett. 506: 33-8. PMID: 11591366
3. Tumor suppressor p27(Kip1) undergoes endolysosomal degradation through its interaction with sorting nexin 6.  |  Fuster, JJ., et al. 2010. FASEB J. 24: 2998-3009. PMID: 20228253
4. Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing.  |  Okada, H., et al. 2010. FASEB J. 24: 2783-94. PMID: 20354142
5. The proximity-labeling technique BioID identifies sorting nexin 6 as a member of the insulin-like growth factor 1 (IGF1)-IGF1 receptor pathway.  |  Bareja, A., et al. 2018. J Biol Chem. 293: 6449-6459. PMID: 29530981
6. Lmo1656 is a secreted virulence factor of Listeria monocytogenes that interacts with the sorting nexin 6-BAR complex.  |  David, DJ., et al. 2018. J Biol Chem. 293: 9265-9276. PMID: 29666193
7. Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.  |  Tomasetto, C., et al. 1995. Genomics. 28: 367-76. PMID: 7490069
8. Involvement of CRAF1, a relative of TRAF, in CD40 signaling.  |  Cheng, G., et al. 1995. Science. 267: 1494-8. PMID: 7533327
9. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.  |  Rothe, M., et al. 1994. Cell. 78: 681-92. PMID: 8069916
10. TRAF6 is a signal transducer for interleukin-1.  |  Cao, Z., et al. 1996. Nature. 383: 443-6. PMID: 8837778
11. Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).  |  Mizushima, S., et al. 1998. Gene. 207: 135-40. PMID: 9511754
12. Identification of a family of sorting nexin molecules and characterization of their association with receptors.  |  Haft, CR., et al. 1998. Mol Cell Biol. 18: 7278-87. PMID: 9819414

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SNX6 Antibody (D-5) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-SNX6 Antibody (D-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SNX6 Antibody (D-5) Specifications

Alternate Product Name: SNX6

Product Clone Name: D-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-40

Epitope Target: SNX6

Epitope Species: human

Product Reactivity/Detection: SNX6

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for SNX6 Antibody (D-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin