SNX2 Antibody (F-8): sc-390510

SNX2 Antibody (F-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects SNX2 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). SNX2 (F-8) antibody is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SNX2 plays a crucial role in intracellular trafficking and sorting of membrane proteins, maintaining cellular homeostasis and regulating signal transduction pathways. SNX2 is involved in endosomal sorting of receptors, including epidermal growth factor receptor, influencing receptor degradation and recycling processes. This function modulates cellular responses to growth factors and ensures proper signal termination, with significant implications in various physiological and pathological contexts, including cancer progression and metabolic disorders. SNX2′s structure features a phox homology (PX) domain that facilitates interaction with phosphoinositides, allowing localization to specific membrane compartments and protein-protein interactions with other sorting nexins and cellular proteins. SNX2′s ability to form complexes with other sorting nexins, such as SNX1 and SNX4, underscores its importance in dynamic regulation of membrane trafficking pathways, making anti-SNX2 antibody (F-8) a valuable tool for researchers studying these critical cellular processes.

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SNX2 Antibody (F-8) References:

1. Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain.  |  Opresko, LK., et al. 1995. J Biol Chem. 270: 4325-33. PMID: 7876194
2. Signal-dependent membrane protein trafficking in the endocytic pathway.  |  Trowbridge, IS., et al. 1993. Annu Rev Cell Biol. 9: 129-61. PMID: 8280459
3. Enhanced degradation of EGF receptors by a sorting nexin, SNX1.  |  Kurten, RC., et al. 1996. Science. 272: 1008-10. PMID: 8638121
4. Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3-kinases: binding partners of SH3 domains?  |  Ponting, CP. 1996. Protein Sci. 5: 2353-7. PMID: 8931154
5. A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor.  |  Horazdovsky, BF., et al. 1997. Mol Biol Cell. 8: 1529-41. PMID: 9285823
6. Identification of a family of sorting nexin molecules and characterization of their association with receptors.  |  Haft, CR., et al. 1998. Mol Cell Biol. 18: 7278-87. PMID: 9819414

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SNX2 Antibody (F-8) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-SNX2 Antibody (F-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SNX2 Antibody (F-8) Specifications

Alternate Product Name: SNX2

Product Clone Name: F-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 313-500

Epitope Target: SNX2

Epitope Species: human

Product Reactivity/Detection: SNX2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for SNX2 Antibody (F-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin