Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Sorting nexin (SNX) proteins are members of a large family of hydrophilic proteins that interact with a variety of receptor types, contain a characteristic phox homology (PX) domain and play a role in intracellular trafficking. Viral infection by a nucleocapsid is initiated when it is transported to late endosomes and, ultimately, to the cytoplasm. This process depends on the late endosomal lipid lysobisphosphatidic acid (LBPA) and its putative effector Alix/AIP1, and is regulated by PtdIns3P (phosphatidylinositol-3-phosphate) signaling via SNX16, its binding protein. Overexpression of SNX16 increases the rate of EGF-induced EGFR degradation and prevents EGF-induced upmodulation of ERK and serum response element (SRE). Mutation in the PX domain eradicates the inhibitory effect of SNX16 on EGF-induced activation of ERK and SRE, suggesting that SNX16 directs the sorting of EGFR to the endosomal compartment, thus regulating EGF-induced cell signaling.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.