SNX16 Antibody (B-4): sc-390523
- SNX16 Antibody (B-4) is a mouse monoclonal IgG1 provided at 200 µg/ml
- raised against amino acids 1-120 mapping at the N-terminus of SNX16 of human origin
- recommended for detection of SNX16 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SNX16 Antibody (B-4). This work is in progress.
SNX16 Antibody (B-4) is a mouse monoclonal IgG1 antibody that detects SNX16 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SNX16 is a crucial member of the sorting nexin family, characterized by its phox homology (PX) domain, which plays a significant role in intracellular trafficking and receptor sorting. SNX16 is primarily located in late endosomes, where SNX16 is essential for the regulation of epidermal growth factor receptor (EGFR) degradation. This localization is vital as SNX16 ensures that EGFR is properly sorted to the endosomal compartment, thereby modulating EGF-induced cell signaling pathways. Notably, overexpression of SNX16 enhances the degradation of EGFR in response to EGF, while mutations in the PX domain disrupt this regulatory function, leading to aberrant activation of downstream signaling cascades such as ERK and serum response element (SRE). SNX16′s ability to interact with late endosomal lipids, such as lysobisphosphatidic acid (LBPA), and its binding partner Alix/AIP1 further underscores SNX16′s importance in the intricate network of cellular signaling and trafficking. With robust performance in various applications, anti-SNX16 antibody (B-4) is an invaluable tool for researchers investigating the dynamics of receptor signaling and intracellular transport mechanisms.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SNX16 Antibody (B-4) | sc-390523 | 200 µg/ml | $322.00 |